炎症小体与慢性肝脏疾病  

Inflammsomes in chronic liver diseases

作　　者：刘姝[1] 王炳元[2] 

机构地区：[1]中国医科大学附属第一医院干诊科,沈阳110001 [2]中国医科大学附属第一医院消化内科,沈阳110001

出　　处：《传染病信息》2013年第5期319-322,共4页Infectious Disease Information

基　　金：辽宁省科技厅科技攻关项目(2011225015)

摘　　要：多种慢性肝脏疾病都与组织的无菌性炎症有关。核苷酸结合寡聚化结构域样受体家族形成的多蛋白复合物———炎症小体,作为炎症反应的核心,能被多种外源或内源性刺激激活,引起下游炎症因子分泌,诱发炎症反应,其过度激活会造成组织损伤。现已证实炎症小体在酒精性和非酒精性脂肪性肝病、肝脏缺血再灌注损伤及药物性肝损伤等疾病中起关键作用,是肝脏发生纤维化和癌变的决定因素之一。本文就炎症小体的结构、活化信号及激活通路、调节机制及其与慢性肝脏疾病关系的研究进展作一综述,以期为慢性肝脏疾病的治疗提供新的方向和靶点。A variety of chronic liver diseases are associated with sterile inflammation of the tissues. Some nucleotide-binding oligomerization domain-like receptors form the inflammasome, a eytosolic muhiprotein complex, which is an important component of sterile inflammation. It can be activated by a large amount of exogenous or endogenous signals, thus inducing the secretion of in- flammatory cytokines and tissue inflammation, and excessive stimulation can cause tissue damage. Research studies have shown that the inflammasome plays a critical role in many chronic liver diseases, such as alcoholic or non-alcoholic fatty liver disease, is- chemia-reperfusion injury of liver and drug-induced liver injury. Inflammasome is an important determinant of liver fibrogenesis and carcinogenesis. This reviewe focuses on the structure of inflammasome, the related activation signal and pathway, regulatory mecha- nism and its association with chronic liver diseases. Further identification of its role may shed light on new approaches for the treat- ment of chronic liver diseases.

关 键 词：肝疾病 慢性病 炎症 半胱氨酸天冬氨酸蛋白酶1 白细胞介素类 

分 类 号：R575[医药卫生—消化系统]