婴儿头皮前B淋巴母细胞性淋巴瘤  

Infant precursor B-cell lymphoblastic lymphoma:a case report

作　　者：孙杰[1] 李雪[1] 张智弘[1] 张美华[1] 鲁严[1] 

机构地区：[1]南京医科大学第一附属医院皮肤科,南京210029

出　　处：《中国麻风皮肤病杂志》2013年第11期701-703,共3页China Journal of Leprosy and Skin Diseases

摘　　要：报道1例婴儿头皮前B淋巴母细胞性淋巴瘤。患儿男,9个月,因头皮肿块,脱发6个月余就诊。皮损表现为7.5 cm×10.5 cm浸润性肿块,呈暗红色,形态不规则,皮损区头发稀疏伴斑状脱发。皮肤活检示真皮及皮下组织弥漫性分布肿瘤细胞,瘤细胞中等大小,胞质少,核呈圆或卵圆形,核仁小,可见核分裂相,表真皮之间有细胞浸润带将表真皮分开。免疫组化CD20、BCL-2、Ki-67和PAX5均呈阳性表达,CD3、TdT、CD30、ALK、CK5/6、CD56、TIA-1、CD43、CD117、穿孔素和颗粒酶B为阴性。We presented a case of infant precursor B-cell lymphoblastic lymphoma. A 9-month-old boy with a skin tumor on his head and alopecia for 6 months. His lesion was infiltrative, measuring 7.5 cm× 10.5 cm with dark-red hue in color and irregular in morphology. Overlying alopecia was observed on the lesion. A biopsy specimen from the scalp demonstrated a diffuse infiltration of atypical tumor cells in the entire dermis and subcutaneous tissue, separated from the epidermis by an infiltration zone. The cells were scant medium to large-sized and had scant cytoplasm, round to oval nuclei with small nucleoli. The cells showed mitotie fig- ures. Immunohisto-chemistry staining showed negative for CD3, TdT, CD30, ALK, CK56, CD56, TIA-1, CD43, CD117, perforin and granzyme B, but positive for CD20, BCL-2, Ki-67 and PAX5.

关 键 词：淋巴母细胞瘤 前B细胞 

分 类 号：R733.1[医药卫生—肿瘤]