圆锥角膜的超微结构研究  

Ultrastructure Study of Keratoconus

作　　者：王琳[1] 成都 刘三梅[2] 蔡如超[1] 成都 邓应平 

机构地区：[1]华西医科大学第一附属医院眼科,成都610041 [2]四川省人民医院眼科

出　　处：《眼科研究》2000年第5期433-435,共3页Chinese Ophthalmic Research

基　　金：本课题为首批四川省优秀青年科技基金资助项目

摘　　要：目的观察圆锥角膜的超微结构变化,拟发现圆锥角膜的特异性改变,为探讨其发病机制提供依据。方法行穿透角膜移植术的圆锥角膜片20例,分别用光镜和电镜观察其各层次的改变。结果圆锥角膜上皮层、基质层变薄,基底膜及前弹力层局限性断裂或破坏;上皮基底细胞水肿,角膜细胞形态、结构改变,并似有异常吞噬现象;基质排列紊乱,板层间可见微粒状沉积物。结论提示圆锥角膜的原发病变可能在角膜基质细胞。ObjectiveTo explore specific changes and to provide evidence for pathogenesis of keratoconus by examining its ultrastructure changes.MethodsTwenty corneal buttons of keratoconus were obtained from penetrating k eratoplasty and changes of every layer w ere observed by light and electron microscopy.Re sultsThe findings were as follows:thin e pithelium and stroma,local rupture and d estruction in basement membranes and Bowm an's layer,basal cell swollen,deformity and structural changes of keratocytes wit h abnormal phagocytosis,stroma disarrange ment,granular deposition among laminae. Conclusion Primary disorder of the keratoconus may lie keratocytes.

关 键 词：圆锥角膜 超微结构 发病机制 KC 

分 类 号：R772.2[医药卫生—眼科]