2型糖尿病初诊时视网膜病变的调查分析及中日比较  

Analysis and comparison of prevalence of diabetic retinopathy between Chinese and Japanese in newly diagnosed type 2 diabetic patients

作　　者：赵志刚[1] 马书平[1] 张菱[1] 田清芬[2] 文世林[1] 付晓英[1] 李全忠[1] 鲁平[1] 周焰[1] 张春玲[3] 大石まリこ 葛谷英嗣 

机构地区：[1]河南省人民医院内分泌科 [2]河南省人民医院眼科 [3]河南财经学院 [4]日本国立京都病院国家糖尿病研究中心

出　　处：《眼科研究》2000年第5期451-453,共3页Chinese Ophthalmic Research

摘　　要：目的调查2型糖尿病(DM)初诊时糖尿病视网膜病变(DR)的患病率及危害因素,比较中国人与日本人DR患病率的异同。方法应用日本DM研究机构设计的方案,以初诊DM患者为研究对象,调查分析DR的患病率及临床特征。结果初诊时中日两组DR的患病率分别为12.30%和14.40%,DR与微量蛋白尿的患病率一致性仅为11.20%。两组的DM家族史,高血压、高血脂的患病率,体重指数(BMI),空腹胰岛素及胰岛素抵抗性存在着差异( P <0.01)。结论DM初诊时已有较高的DR患病率,糖代谢异常与HbA1c升高可能是DR的独立危害因素,提示DM的早期防治是阻止DR发生、发展的重要措施。ObjectiveTo investigate the prevalence of diabetic retinopathy(DR) between Chinese and Japanese.MethodsAltogether there were 736 Chinese and 1.011 Japanese patients with type 2 diabetes mellitus(DM) who were se parately from China and Japan.The complications of DR and microalbuminuria(MAU) were diagnosed According to WHO criteria of DM and study protocol of Kyoto National Hospital Diabetes center in Japan.R esults The prevalence rates of DR were 12.30% in chinese,and 14.00% in Japanese and MAU was presented in 31.80%,23.40% of Chinese and Japanese group res pectively.The overall prevalence of DR and MAU was less(11.2%) than newly dia gnosed patients.The inheritance background of DM was different between the two groups,which was more frequent in Japanese group ( p <0.01).Body mass index,fasting plasma insulin and homestasis model assessment(HOM A) were higher in Chinese than Japanese group.The prevalence of hypertension(HT) and dyslipidemia in Chinese were statistically higher than Japanese group.The fasting blood sugar(FBS,10.44mmol/L,10.21mml/L)was close to hemoglobin A1c(HbA1c,8 .11%,8.85%).Conclusions The prevalence of DR and MAU is higher in newly type 2 DM patients both Chinese and Japanese groups. The statistically significant risk factors for DR are likely due to the increase in FBS,HbA1c. Risk factors such as hypertensi on,obesity and dyslipidemia are found in the patients with MAU.The results sugge st that early diagnosis and correction of these abnormalities are crucial to pre vent chronic diabetic complications

关 键 词：Ⅱ型糖尿病 视网膜病变 微量白蛋白尿 诊断 

分 类 号：R774[医药卫生—眼科]