胃癌患者手术前后外周血细胞因子IFN-γ、IL-4和TGF-β水平变化  

The variation of cytokine IFN-γ、IL-4 and TGF-β in pre/post-operation peripheral blood of gastric cancer patients

作　　者：李科军[1] 周志华[1] 向正国[1] 郑扬[1] 杨胜兰[1] 陈旭峰[1] 

机构地区：[1]解放军第101医院消化科,江苏无锡214000

出　　处：《海南医学院学报》2013年第11期1503-1505,1508,共4页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210845)~~

摘　　要：目的：观察胃癌患者手术前后外周血细胞N子IFN-γ、IL-4和TGF-β水平变化。方法：选取胃癌患者40例为胃癌组，选取同期健康体检者40例为对照组，采用ELISA法检测胃癌组患者手术前后和对照组健康体检者血清IFN-γ、IL-4和TGF-β水平。结果：与对照组比较，胃癌组、I～Ⅱ级组和Ⅲ～Ⅳ级组血清IFN-γ、IL-4和TGF-β水平明显升高，差异有统计学意义（P〈0．05）；与I～Ⅱ级组比较，Ⅲ～Ⅳ级组血清IFN-γ、IL-4和TGF-β水平升高，差异有统计学意义（P％0．05）；与手术前比较，手术后患者血清IFN-γ、IL-4和TGF-β水平显著降低，差异有统计学意义（P〈0．05）；直线相关分析结果显示，胃癌组患者血清IFN-γ、IL-4和TGF-β彼此之间呈正相关（P〈0．05）。结论：血清细胞因子IFN-γ、IL-4和TGF-β水平与胃癌的发生、发展及预后密切相关，提示血清细胞因子联合检测对认识胃癌的发病机理及疗效判断有着重要的临床指导意义。Objective= To observe the variation of cytokine IFN-γ、IL-4andTGF-β in pre/pos eration peripheral blood of gastric carcinoma patients. Methods= A total o{ 40 patients with gastric car ma were selected as gastric carcinoma group, at the same time, 40 healthy adults were selected as co group, the ELISA method was used to detect the variation of cytokine IFN-γ、IL-4andTGF-β in pre/ operation peripheral blood of all participants. Results. Comparing with control group, the serum IF t-op- cino- ntrol post- IFN-γ、IL-4andTGF-β levels of gastric carcinoma group. I -II stage group and III - IV stage group increased sig- nificantly, the difference was statistically significant （P〈0.05）, and comparing with I - 1I stage group, the serum IFN-γ、IL-4andTGF-β levels of III - IV stage group also increased, the difference was statisti- cally significant （P〈0.05） ;comparing with pre-operation level, the serum IFN-γ、IL-4andTGF-β levels of post-operation significantly decreased, the difference was statistically significant （P〈0.05） ;The linear correlation analysis result showed that the serum IFN-γ、IL-4andTGF-β levels of gastric carcinoma were positively related to each other（P〈0.05）. Oonclusion： The variation of cytokine IFN-γ、IL-4andTGF-β are closely associated with the occurrence, development and prognosis of gastric carcinoma indicating that the joint detection of serum cytokines will help to understand the pathogenesis and curative effects judg- ment of gastric carcinoma.

关 键 词：胃癌 手术 细胞因子 

分 类 号：R735.2[医药卫生—肿瘤]