“血清药物化学-药代(效)动力学-系统生物学”三维整合体系研究中药复方的构建及其在茵陈蒿汤分析中的应用  

Establishment of three-dimensional integrated "serum pharmacochemistry- pharmacokinetics(pharmacodynamics)-systems biology" for research of traditional Chinese medicine prescription and its application in Yinchenhao Tang

作　　者：张爱华[1] 孙晖[1] 闫广利[1] 韩莹[1] 王喜军[1] 

机构地区：[1]黑龙江中医药大学中药血清药物化学国家中医药管理局重点实验室,黑龙江哈尔滨150040

出　　处：《中国中药杂志》2013年第21期3786-3789,共4页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502-005);国家自然科学基金面上项目(81173500;81373930);国家自然科学基金青年科学基金项目(81302905;81202639);国家自然科学基金重大研究计划(90709019)

摘　　要：中药复方是中医临床用药的宝贵财富,多成分、多靶点是其特色和优势所在。然而中药复方成分复杂,药效物质基础、作用机制不清,量-效关系缺乏科学的数据支持,已成为其深入研究的瓶颈,严重阻碍了中医药的现代化和国际化进程。这需要整合中医药理论、现代分析及数据挖掘技术构建符合中医药特色的复方研究新模式。该文扼要介绍了中药血清药物化学、中药药代动力学的研究现状、系统生物学理论及实践,在此基础上提出应用"血清药物化学-药代(效)动力学-系统生物学"(SPS)三维整合体系方法来研究中药复方,以期揭示药效物质基础和作用机制及其配伍科学内涵,并结合茵陈蒿汤研究进行相关说明。Traditional Chinese medicine （TCM） prescription is a valuable asset for clinical medication, has multi-component and multi-target characteristics. However, due to the complex ingredients of prescription, the unclear mechanism, the lack of scientific data to support the dose-response relationship, it has become the bottleneck for the in-depth study for the process of modernization and internationalization of TCM. It requires the integration of Chinese medicine theory, modern analysis and data mining technology to build new research model for characteristic of TCM prescription. This paper provides an overview of TCM serum pharmacochemistry, pharmacokinetics （pharmacodynamics） and systems biology theory and practice, to establish the integrated three-dimensional ＂serum pharmacochemistry-pharmacokinetics（pharmacodynamics）-systems biology＂ for the research of TCM prescription to reveal the pharma-material basis and action mechanism and the compatibility scientific connotation, with a prescription Yinchenhao Tang as a case study.keywords：traditional Chinese medicine serum pharmacochemistry

关 键 词：中药血清药物化学 系统生物学 中药复方 药效物质基础 生物标记物 

分 类 号：R289[医药卫生—方剂学]