阿司匹林多单元肠溶片的制备及体外溶出度考察  

Preparation and in vitro evaluation of multi-unit tablets of delayed release aspirin

作　　者：刘文丽[1] 韩海岭 韩建生[1] 

机构地区：[1]上海医药集团股份有限公司中央研究院,上海201203 [2]赢创特种化学(上海)有限公司,上海201108

出　　处：《上海医药》2013年第21期51-53,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:研制阿司匹林多单元肠溶微丸片。方法:采用阿司匹林粉末包衣先制备肠溶包衣微粒,再与适量辅料混合后直接压片制备肠溶阿司匹林微粒片,并对影响其质量的关键因素进行了考察。结果:制备的微粒片溶出度符合阿司匹林肠溶制剂质量的标准要求。Objective： To prepare multi-unit tablets of delayed release aspirin. Methods： Delayed release particle was made by aspirin powder coating technology, to which coated particles was mixed with other excipient and then direct compress was used to make multiple particle tablets. Meanwhile some important factors affecting product quality were studied. Results： Release profile of this multi-unit tablets complies to the specification of delayed release aspirin.

关 键 词：肠溶 微粒 阿司匹林 包衣 

分 类 号：R944.4[医药卫生—药剂学] R927.11[医药卫生—药学]