低剂量^(60)Coγ射线与雌性激素联合诱发SHE细胞恶性转化的实验研究  

MALIGNANT TRANSFORMATION OF SYRIAN HAMSTER EMBRYO CELLS IN VITRO BY LOW-DOSE OF ^(60)Co γ-RAY COMBINED WITH FEMALE SEX HORMONES

作　　者：余璐[1] 高凤鸣[1] 

机构地区：[1]卫生部工业卫生实验所

出　　处：《辐射研究与辐射工艺学报》1991年第1期34-38,共5页Journal of Radiation Research and Radiation Processing

摘　　要：本实验应用金黄地鼠胚胎(SHE)细胞,研究了低剂量^(60)Coγ线与雌性激素(EP)联合诱发细胞恶性转化的作用。实验结果表明两种因素联合应用,致癌作用加强。同时也证明,哺乳动物细胞的恶性转化是一个多阶段的生物学过程。Malignant transformation of syrian hamster embryo(SHE) cells invitro was induced by low-dose of ^(60)Co γ-ray combined with EP. The transformationwas not observed in the groups that the γ-rays or EP was given alone. The results snggested that the combination of low-dose of γ-ray and EP mayhave the synergetic effect of carcinogenesis on cells in vitro. The results also showedthat transformation of cells in vitro is a multistage processes.

关 键 词：SHE细胞 雌性激素 Γ射线 辐照 

分 类 号：R730.231.2[医药卫生—肿瘤]