慢性愤怒应激对脑老化大鼠学习记忆及血浆单胺类神经递质的影响  

Effects of chronic anger stress on learning and memory and plasma monoamine neurotransmitters of rats with brain aging

作　　者：刘胜利[1] 詹向红[1] 李伟[1] 王淑玲[2] 赵君玫[1] 王友杰[1] 刘高建[1] 王慧霞[1] 

机构地区：[1]河南中医学院,郑州450008 [2]郑州大学医学院,郑州450001

出　　处：《中华中医药杂志》2013年第11期3185-3187,共3页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金(No.30772686;No.30973695)~~

摘　　要：目的:探讨慢性愤怒应激对大鼠脑老化进程及血浆单胺类神经递质水平的影响。方法:在D-半乳糖(D-gal)衰老及脑老化模型基础上引入愤怒刺激,用Morris水迷宫实验观察慢性愤怒应激对大鼠空间学习记忆能力的影响,并测定血浆中单胺类神经递质去甲肾上腺素(NE)、5-羟色胺(5-HT)、多巴胺(DA)的含量。结果:与模型组比较,愤怒应激组大鼠空间学习记忆能力明显下降,血浆NE、DA升高,5-HT降低。结论:慢性愤怒应激加重D-gal大鼠脑老化程度,加速衰老进程;单胺类神经递质紊乱可能是其发生的机制之一。Objective： To discuss the effects of chronic anger stress on rats＇ brain aging progress and concentration of plasma monoamine neurotransmitters. Methods： Induced anger stimulation after building D-gal aging and brain aging model, we observed the effects Of chronic anger stress on the spatial learning and memory of rats by Morris water maze, and measured the contents of plasma monoamine neurotransmitters： norepinephrine （NE）, 5-hydroxytryp-tamine（5-HT）, dopamine（DA）. Results： Compared with the model group, the rats＇ spatial learning and memory in the angry stress group decreased obviously, the contents of NE and DA in plasma in the angry stress group increased, the contents of 5-HT decreased. Conclusion： The rats＇ brain aging was aggravated by chronic anger stress, the aging was accelerated; the rat＇s monoamine neurotransmitters disorder may be one of the mechanisms.

关 键 词：愤怒应激 脑老化 单胺类神经递质 

分 类 号：R363[医药卫生—病理学]