川崎病患儿血11β-羟基类固醇脱氢酶的变化研究  

Changes of 11-beta hydroxysteroid dehydrogenase level in plasma of children with Kawasaki disease

作　　者：王娟莉[1] 周南[1] 苏德成[1] 王涛[1] 高晓鹏[1] 

机构地区：[1]西安市儿童医院,陕西西安710003

出　　处：《中国妇幼健康研究》2013年第5期643-645,共3页Chinese Journal of Woman and Child Health Research

摘　　要：目的研究川崎病患儿外周血11β-羟基类固醇脱氢酶(11β-HSD)的变化,为应用糖皮质激素治疗川崎病提供理论依据。方法检测并比较病例组、健康对照组患儿及病例组患儿丙种球蛋白(2g/kg)治疗前、治疗后第3天外周血中11β-HSD_1和11β-HSD_2的水平。结果 11β-HSD_1水平免疫球蛋白治疗前病例组(8.21±2.83ng/mL)高于对照组(6.61±0.65ng/mL),两组间比较有显著性差异(t=3.29,P<0.05);治疗后病例(5.63±3.36ng/mL)组低于对照组(6.61±0.65ng/mL),两组间比较无显著性差异(P>0.05)。11β-HSD_2水平免疫球蛋白治疗前病例组(2.30±1.46ng/mL)低于对照组(3.18±1.34ng/mL),两组间比较有显著性差异(t=-2.62,P<0.05);治疗后病例组(2.98±1.43ng/mL)低于对照组(3.18±1.34ng/mL),两组间比较无显著性差异(P>0.05)。结论川崎病发病初期,体内存在的炎症因子影响11β-HSD的表达。早期应用糖皮质激素可能会发挥更有效的抗炎作用。Objective To investigate the changes of 11-beta hydroxysteroid dehydrogenase （ 11β-HSD ） levels in peripheral blood of children with Kawasaki disease （KD）, so as to provide theoretical basis for application of glucocorticoid （GC） in the treatment of KD. Methods The levels of 11β-HSD1 and 11β-HSD2 in peripheral blood were respectively detected in case group , healthy control group and in case group before and 3 days after the treatment with immunoglobulin （2g/kg）.Results Before the treatment with immunoglobulin the level of 11β-HSD1 of case group （8.21 ±2.83ng/mL） was higher than that of the control group （6.61 ±0.65ng/mL）.Comparison between two groups showed significant difference （t=3.29, P〈0.05）.But the level of 11β-HSD1 of case group after treatment （5.63 ±3.36ng/mL） was lower than that of the control group （6.61 ±0.65ng/mL）, and there was no significant difference between them （P〉0.05）.The level of 11β-HSD2 of case group （2.30 ±1.46ng/mL） was lower than that of the control group （3.18 ±1.34ng/mL） prior to treatment, and the difference was significant （t=-2.62,P〈0.05）.After treatment the level of 11β-HSD2 of case group （2.98 ±1.43ng/mL） was lower than that of the control group （3.18 ±1.34ng/mL）, and there was no significant difference between them （P〉0.05）.Conclusion In the early stage of KD , inflammatory factor can influence the expression of 11β-HSD.Early use of corticosteroids may exert more effective anti-inflammatory effect .

关 键 词：川崎病 糖皮质激素 11Β-羟基类固醇脱氢酶 外周血 

分 类 号：R983.1[医药卫生—药品]