老年急性缺血性脑梗死患者血清N端脑钠肽前体水平的变化及意义  

Variation and significance of N-terminal pro-brain natriuretic peptide levels in serum in elderly patients with acute ischemic stroke

作　　者：汪进丁[1] 万和斌[1] 万姗姗[1] 文师访 彭经华 

机构地区：[1]江西省九江市第一人民医院神经内科,江西九江332000

出　　处：《中国当代医药》2013年第31期46-48,共3页China Modern Medicine

基　　金：江西省九江市2012年科技局课题(2012-004)

摘　　要：目的分析老年急性缺血性脑梗死患者N端脑钠肽前体(NT-pro-BNP)水平的变化,探讨NT-pro-BNP与老年缺血性脑梗死的关系。方法连续选取本院的老年急性缺血性脑梗死患者85例,健康体检者(对照组)30例,在入院2 d内测定各组血清NT-pro-BNP水平及NIHSS评分,并进行组间比较。按TOAST分为心源性脑梗死组(27例),非心源性脑梗死组(58例),按梗死面积大小分为大面积梗死(32例)组、小面积梗死(53例)组。结果脑梗死组血清NT-pro-BNP值显著高于正常对照组(P<0.01),心源性脑梗死组NT-pro-BNP水平显著高于非心源性脑梗死组(P<0.01),大面积脑梗死组血清NT-pro-BNP值明显高于小面积脑梗死组(P<0.01)。结论老年急性缺血性脑梗死患者血NT-pro-BNP水平升高,梗死面积越大,血清NT-pro-BNP值越高,预后越差。血NTpro-BNP水平不仅能预测脑梗死病变程度,而且有可能预测脑梗死预后。Objective To analyze the levels of N-terminal pro-brain natriuretic peptide （NT-pro-BNP） in patients with acute ischemic stroke and probe into the relationship between NT-pro-BNP and ischemic stroke of elderly. Methods 85 patients with acute ischemic stroke admitted into our hospital and 30 healthy participants （control group） were selected. The levels of NT-pro-BNP from serum and national institutes of health stroke scale （NIHSS） were test- ed within 2 days after being hospitalized in each group. The outcomes would be compared. According to TOAST, these patients were divided into cardiac cerebral infarction group （n=27） and non-cardiac cerebral infarction group （n=58）. If based on infarct size, they were divided into large area infarction group （n=32） and small area infarction group （n=53）. Results The level of NT-pro-BNP in the cerebral infarction group was remarkably higher than that in the control group （P〈0.01）, compared with non-cardiac cerebral infarction group, the NT-pro-BNP level in the cardiac cerebral infarction group was much higher （P〈0.01）, the value of NT-pro-BNP in large area infarction group was higher than that in small area infarction group （P〈0.01）. Conclusion With increase of NT-pro-BNP levels in elderly patients with acute ischemic stroke, the infarction area will become larger and prognosis will be poorer. Therefore, the value of NT- pro-BNP not only predicts the severity of cerebral infarction but also the prognosis.

关 键 词：急性缺血性脑梗死 N端-脑钠肽前体 脑梗死 老年人 

分 类 号：R743.3[医药卫生—神经病学与精神病学]