中国人群9号染色体10个STR基因座的遗传多态性及其在法医学中的应用  

Genetic polymorphism of 10 STR loci on chromosome 9 and its forensic application in Chinese population

作　　者：张霁[1] 侯一平[1] 吴谨[1] 李英碧[1] 廖林川[1] 王玉芳 魏玉峰 

机构地区：[1]华西医科大学法医学院物证教研室，成都 610041 [2]甘肃白银公司职工医院

出　　处：《中华医学遗传学杂志》2000年第6期417-421,共5页Chinese Journal of Medical Genetics

基　　金：CMB基金(96-636)

摘　　要：目的　了解 9号染色体 10个 STR基因座在中国汉族群体的遗传多态性及其法医学应用价值。方法　无血缘关系的 83份个体样本采自甘肃省白银地区汉族群体。 18个无关汉族家系共 131份血样采自同一地区。PCR扩增 9号染色体 10个 STR基因座。PCR产物由非变性聚丙烯酰胺凝胶电泳分析。结果　 10个 STR基因座在中国汉族群体均具有遗传多态性。家系调查结果表明 ,10个 STR基因座在世代传递中遵循孟德尔常染色体共显性遗传规律。结论　为人类群体遗传研究提供了 9号染色体 10个 STR基因座的中国汉族群体数据。Objective To have a thorough knowledge of the genetic polymorphism of 10 short tandem repeats loci of chromosome 9 in Chinese population and its application in forensic science. Methods The 9 STR tetrameric loci and one trimeric tandem repeat locus were chosen from Genome Databank. Eighty three EDTA blood samples were collected from the unrelated family in Baiyin city, Gansu province. DNA was extracted by Chelex method and amplified by the polymerase chain reaction(PCR). The PCR products were analyzed by PAGE electrophoresis. Results The polymorphisms of all 10 STR loci have been obtained in Chinese Han population. The 10 STR loci follow the Mendel's law. Conclusion The data of all 10 STR loci is beneficial to understanding the population genetics of them in Chinese Han population.

关 键 词：9号染色体 短串联重复序列 遗传多态性 汉族 法医学 

分 类 号：Q346.5[生物学—遗传学] D919.4[医药卫生—法医学]