全身奥曲肽显像在神经母细胞瘤诊断及预后判断的价值:附14例报告  

Application of systemic octreotide radioactive imaging in children with neuroblastoma: a report of 14 cases

作　　者：张谊[1] 黄东生[1] 

机构地区：[1]首都医科大学附属北京同仁医院儿科,北京100730

出　　处：《临床儿科杂志》2013年第11期1050-1053,共4页Journal of Clinical Pediatrics

基　　金：北京科委首都临床特色项目资助(No.D101100050010052)

摘　　要：目的：探讨全身奥曲肽显像在神经母细胞瘤（neuroblastoma，NB）诊断及预后判断的价值。方法回顾性分析2006年4月-2011年3月收治的14例行全身奥曲肽显像检查的NB患儿临床资料。初诊病例均于常规治疗后第1次随访时行全身奥曲肽显像检查；因复发或疑似复发就诊病例于治疗前及化疗2、3个周期后行全身奥曲肽显像检查进行对比。结果14例NB患儿，男9例、女5例，中位年龄4.8岁（1~10岁），III期4例、IV期10例。8例于原发部位和（或）转移部位摄取率高于正常，阳性率57.14%（8/14），经治疗或影像学验证1例为假阳性；6例原发部位或转移部位摄取率处于正常范围，阴性率42.86%（6/14），经治疗或影像学验证1例为假阴性；奥曲肽显像诊断符合率达85.71%（12/14）。结论全身奥曲肽显像检查可作为NB诊断及随访的辅助检查项目之一，对NB预后评估具有一定价值。Objectives To evaluate the application of systemic octreotide radioactive imaging in diagnosis and follow-up for children with neruoblastoma （NB）. Methods Clinical data of 14 children with NB applied systemic octreotide radioac-tive imaging from April 2006 to March 2011 were collected and analyzed. For the ifrst-visit patients, they were applied with systemic octreotide radioactive imaging at the ifrst follow-up appointment after routine treatment. And for recurrent or sus-pected recurrent cases, systemic octreotide radioactive imaging was applied before the treatment and after 2-3 weeks chemo-therapy. Results Nine of 14 patients were male and 5 were female with a median age of 4.8 years （1-10 years）. According to In-ternational Neuroblastoma Staging System （INSS）, 4 cases were categorized as stage 3 and 10 cases were categorized as stage 4. The uptake rate of systemic octreotide radioactive imaging in primary site or metastasis sites of 8 cases were higher than nor-mal site with positive rate of 57.14%（8/14）. One case was conifrmed as false positive by treatment and imaging examination. Six cases were negative in primary site or metastasis sites with negative rate of 42.86%（6/14）. One case was conifrmed as false negative via treatment and imaging examination. Therefore, the sensitivity of systemic octreotide radioactive imaging reached 85.71%（12/14）. Conclusion Systemic octreotide radioactive imaging could be one of the effective methods for NB in diagno-sis, follow-up and evaluation of prognosis.

关 键 词：神经母细胞瘤 奥曲肽 核素 诊断 评估 儿童 

分 类 号：R739.4[医药卫生—肿瘤]