电针对血管性痴呆大鼠血清、脑组织中乙酰胆碱酯酶活性及学习记忆能力的影响  

Effects of Electroacupuncture on Serum and Cerebral AchE Activity and Learning-memory Ability in Vascular Dementia Rats

作　　者：高康[1] 李飞[2] 张庆萍[3] 翟亮[3] 

机构地区：[1]武汉市中医医院,湖北武汉430010 [2]安徽中医药大学附属针灸医院,安徽合肥230061 [3]安徽中医药大学,安徽合肥230038

出　　处：《辽宁中医杂志》2013年第11期2367-2368,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81001558)

摘　　要：目的:观察电针中冲、涌泉穴对VD大鼠血清、脑组织中乙酰胆碱酯酶(AchE)活性及学习记忆能力的影响。方法:四血管阻断法制作VD大鼠模型,将VD大鼠随机分为模型组、电针组和西药组。采用跳台试验检测学习记忆能力;采用ELISA法测定AchE活性。结果:电针组大鼠跳台反应期时间比模型组缩短(P<0.05);电针组大鼠脑组织和血清中AchE活性显著低于模型组(P<0.01)。结论:电针能改善VD大鼠血清和脑组织中AchE活性,从而提高VD大鼠学习记忆能力。Objective：To observe the effect of electroacupuncture （EA） at Zhongchong and Yongquan on metabolism of learning - memory ability and Ache activity in serum and cerebral of VD rats. Methods ： VD model was established by using modified 4 - vessels occlusion method. The VD rats were randomly divided into model, EA and medication groups. The changes of learning- memory ability were investigated by step-down test. AchE activity was measured by ELISA. Results ： The EA group reaction period of step-down test was decreased compared with those in the model group （ P 〈 0. 05 ）. Serum and cerebral AchE activity in EA group was considerably lower than those in model group （ P 〈 0. 01 ）. Conclusion ： EA can reduce serum and cerebral AchE activity, and improve the learning- memory ability in VD rats.

关 键 词：电针 血管性痴呆 乙酰胆碱酯酶 

分 类 号：R743[医药卫生—神经病学与精神病学]