143例肿瘤患者应用抗肿瘤药物不良反应临床分析  

Adverse Drug Reaction Analysis of Antineoplastics:an Analysis of 143 Cases in Our Hospital

作　　者：吴芳[1] 王玮[1] 张红果[1] 羿凤云 

机构地区：[1]中国人民武装警察部队总医院药剂科,100039 [2]中国人民武装警察部队北京市总队第三医院药械科,100141

出　　处：《实用癌症杂志》2013年第6期762-764,共3页The Practical Journal of Cancer

摘　　要：目的探讨肿瘤患者应用抗肿瘤药物不良反应发生的规律及特点。方法以143例肿瘤患者为研究对象,对其抗肿瘤药物应用的各项不良反应。结果不良反应发生以老年人多见,多发生于用药24 h内。给药途径以静脉滴注及注射更易发生不良反应,抗肿瘤药造成的不良反应最多,紫杉醇、奥沙利铂、氟尿嘧啶、高聚生及巴曲亭更容易产生严重不良反应。联合用药中,单联及二联用药最易产生不良反应。结论临床中需加强对抗肿瘤药物不良反应的预防及监测。Objective To study the characteristics and regularities of adverse drug reactions （ADR） of tumor patients. Methods 143 cancer patients were selected in our hospital for research,their clinical data and ADR were retrospectively analyzed. Results ADR occurred mainly in elderly patients 24h after medication. Intravenous infusion and injection had highest incidence rate of ADR. Antineoplastic drugs had many adverse reactions, paclitaxel, oxaliplatin, fluorouracil, highly agglutinative staphylococcin and hemocoagulase were most likely to cause serious adverse drug reactions. Medication of single drug and duplex drugs are most likely to cause the occurrence of adverse drug reactions. Conclusion ADR induced by anticancer drugs should be given more attention.

关 键 词：药物不良反应 分析 用药 

分 类 号：R730.53[医药卫生—肿瘤]