海藻酸钠/淀粉复合微球的制备及性能研究  

Research on synthesis and performance of SA/ST microspheres

作　　者：杨延慧[1] 张永臻[1] 陈惠[1] 严涵[1] 陈晓浪[2] 王晓敏[1] 王萃娟[1] 周先礼[1] 张志斌[1] 

机构地区：[1]西南交通大学生命科学与工程学院,成都610031 [2]西南交通大学材料科学与工程学院,成都610031

出　　处：《化工新型材料》2013年第11期44-46,共3页New Chemical Materials

基　　金：国家自然科学基金资助项目(51003088;50573061);中央高校基本科研业务费专项资金资助(2010ZT09;SWJTU12CX047;SWJTU12CX048)

摘　　要：以SA和ST为基质材料制备SA／ST复合微球，由单因素固定变量实验对SA／ST复合微球的合成进行研究，得到最佳实验条件为：总质量分数为6％，SA、ST质量比例为3：1。由红外光谱分析样品的化学结构，发现SA和ST之间通过氢键作用复合。研究结果表明，SA和ST总质量分数为6％时，微球有较高的包埋率和载药量，分别为65．00％和3．23％。载药微球在5～6h就可以达到完全释药，实验表明随着总质量分数增大微球的释药率降低。复合微球的溶血率为1．9％，小于国家标准5％，证明SA／ST复合微球有较好的血液相容性。The SA/ST composite microspheres were synthesized with sodium alginate and starch. The syntheses of SA/ST microspheres were studied by experiment of fixing single factor. The results showed that excellent conditions of SA/ST microspheres were the total mass of 6%, the mass fraction of SA to ST of 3 ： 1. SA and ST made interaction through hydrogen bond by FTIR. The result showed that when SA/ST total mass fraction of 6 %, microspheres had better encapsulation efficiency and drug loading rate,i, e. 65.00% and 3. 23% respectively. The drug-loaded microspheres could release completely in 5-6 hours. The result demonstrated that the drug releasing efficiency of microspheres decreased with the increasing of the total mass fraction. The hemolysis ratio was 1.9%,less than the national standard of 5 %. It indicated that SA/ST mierospheres were hemocompatible.

关 键 词：海藻酸钠 可溶性淀粉 微球 

分 类 号：TB33[一般工业技术—材料科学与工程]