重症急性胰腺炎应用连续性血液净化治疗疗效分析  

Application of Continuous Blood Purification Treatment Efficacy Analysis for Severe Acute Pancreatitis

作　　者：鲁庆红 李益明[1] 王志芳[1] 祝亮[1] 张玲[1] 

机构地区：[1]湖北省黄冈市中心医院,湖北黄冈438000

出　　处：《中国医学创新》2013年第32期35-36,共2页Medical Innovation of China

摘　　要：目的:探讨重症急性胰腺炎(SAP)患者应用连续性血液净化治疗的临床效果及对炎症细胞因子的影响。方法:选取本院2010年1月-2012年12月收治的SAP患者10例为研究对象,随机将患者分为对照组5例(常规治疗)及观察组5例(常规治疗+连续性血液净化治疗)。对比分析两组患者治疗前后白细胞介素-1、6、8(IL-1、6、8)以及肿瘤坏死因子(TNF-a)的水平变化;同时观察两组患者的机械通气时间及住院时间。结果:观察组治疗后IL-1(101.2±10.9)ng/L、IL-6(149.5±11.8)ng/L、IL-8(88.2±8.3)ng/L以及TNF-a(221.4±33.5)ng/L,显著低于对照组的IL-1(147.8±40.2)ng/L、IL-6(197.4±38.5)ng/L、IL-8(118.4±22.8)ng/L、TNF-a(345.5±31.2)ng/L,差异均有统计学意义(P<0.05);观察组机械通气时间(5.3±1.2)d、住院时间(8.5±2.4)d显著短于对照组的(8.3±1.4)d、(12.5±2.1)d,差异具有统计学意义(P<0.05)。结论:对SAP患者采用连续性血液净化能有效改善患者炎症细胞水平,缩短患者机械通气时间及住院时间。Objective：To investigate patients with severe acute pancreatitis（SAP）application of the clinical effects of continuous blood purification treatment and the impact of inflammatory cytokines in patients. Method：10 cases of SAP were selected in our hospital from January 2010 to December 2012 for the study,were randomly divided into the control group（conventional treatment）and observation group（conventional treatment and continuous blood purification treatment）. Compared interleukin-1,6,8（IL-1,6,8）and tumor necrosis factor（TNF-a）levels of two groups before and after treatment. While observed the two groups of duration of mechanical ventilation and length of stay. Result：After treatment,the observation group IL-1（101.2±10.9）ng/L,IL-6（149.5±11.8）ng/L,IL-8（88.2±8.3）ng/L and TNF-a（221.4±33.5）ng/L were significantly lower than the control group IL-1（147.8±40.2）ng/L,IL-6（197.4±38.5）ng/L,IL-8（118.4±22.8）ng/L,TNF-a（345.5±31.2）ng/L and the differences were statistically significant（P〈0.05）. The duration of mechanical ventilation（5.3±1.2）d,length of hospital stay（8.5±2.4）d in the observation group were shorter than （8.3 ± 1.4）d,（12.5 ± 2.1）d in the control group（P〈0.05）. Conclusion：SAP patients using continuous blood purification can effectively improve the level of inflammatory cells in patients with to shorten patients with mechanical ventilation and length of stay.

关 键 词：重症急性胰腺炎 连续性血液净化 临床疗效 

分 类 号：R576[医药卫生—消化系统]