纤维化肝脏中肌成纤维细胞的来源  

Sources of myofibroblasts in liver fibrosis

作　　者：周亚宁[1] 慕永平[1] 刘平[1] 

机构地区：[1]上海中医药大学附属曙光医院肝病研究所,上海市201203

出　　处：《世界华人消化杂志》2013年第31期3376-3382,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81273728~~

摘　　要：肌成纤维细胞(myofibroblasts,MFBs)通过合成并分泌胶原促进肝脏细胞外基质(extracellular matrix)的累积,导致肝纤维化的发生、发展,其来源广泛.肝损伤时肝纤维化发展中的关键细胞-活化的肝星状细胞(hepatic stellate cells)是MFBs的主要来源;更有数据表明肝细胞和胆管上皮细胞在特定条件刺激下可以通过上皮-间质转分化(epithelial-tomesenchymal transition)过程转变为MFBs,但也有不少研究否定了该结论,因此也成为目前的研究热点之一;越来越多的研究表明,来源细胞包括汇管区成纤维细胞、骨髓细胞、肝内祖细胞等.因此本文就MFBs来源的研究进展做一综述.Myofibroblasts （MFBs） promote the accumula- tion of the extracellular matrix （ECM） by synthe- sis and secretion of collagen in the liver, leading to liver fibrosis. Activated hepatic stellate cells （HSC） are the major source of MFBs, and also play a key role in the development of liver fi- brosis. Many studies indicate that hepatocytes and bile duct cells may undergo epithelial-to- mesenchymal transition （EMT） to MFBs; how- ever, contrary conclusions have also been drawn in recent studies. In addition, other sources of MFBs have also been found, including portal fibroblasts, bone marrow cells, and hepatic pro- genitor cells. In this article we will review the sources of MFBs in liver fibrosis.

关 键 词：肝纤维化 肌成纤维细胞 

分 类 号：R575.2[医药卫生—消化系统]