山东省菏泽市隔膜型布加综合征的空间聚集性分析  

Spatial clustering analysis of Budd-Chiari syndrome in Heze City of Shandong Province

作　　者：高杰[1] 肖培瑞[2] 薛付忠[2] 蔺新英[2] 边建朝[1] 

机构地区：[1]山东省地方病防治研究所地方性氟中毒与大骨节病防治研究科,济南250014 [2]山东大学公共卫生学院

出　　处：《中华地方病学杂志》2013年第6期632-635,共4页Chinese Journal of Endemiology

基　　金：国家自然科学基金（30772134）

摘　　要：目的探讨山东省菏泽市隔膜型布加综合征的空间分布特征及聚集区域，为进一步了解该病的病因及可能危险因素提供流行病学线索。方法收集1995—2004年在菏泽市立医院、菏泽单县中心医院、徐州医学院附属医院、山东省立医院、北京宣武医院就诊的居住地为山东省菏泽市的342例隔膜型布加综合征患者的详细居住地址资料。以地理信息系统（GIS）为数据管理和显示平台，综合应用最近邻指数、Ripley’sK（d）函数、Ripley’SL（d）函数和最近邻空间系统聚类方法揭示山东省菏泽市隔膜型布加综合征的空间分布特征。应用Cnmestat3．0软件进行空间分析。结果最近邻指数为0．6767（Z=一11．4387，P〈0．叭），即在一阶空间尺度具有聚集性。Ripley’sK（d）结果显示，在研究区域内，隔膜型布加综合征的第一聚集尺度为6．66km，第一聚集强度为5．40；最强聚集区的平均半径为126．61km，平均聚集强度为12．52；最大强聚集尺度大于222km。而进行人口校正后，Ripley’sL（d）函数与校正前基本一致，聚集强度略高于校正前。最近邻空间系统聚类结果显示，菏泽市隔膜型布加综合征的一阶空间聚集热点为10个，而95％可信区间的聚集个数为7，聚集结果具有统计学意义（P〈0．05）。在一阶聚集的基础上产生1个二阶聚集热点见结果，主要分布在牡丹区、单县、鄄城等地。结论山东省菏泽市隔膜型布加综合征的空间分布呈现空间聚集性和异质性，这对于进一步探讨病因具有重要流行病学意义。Objective To investigate the spatial distribution and clustering areas of Budd-Chiari syndrome in Heze City, Shandong Province, and to provide epidemiological information for further exploring the etiology and related risk factors of the disease. Methods Detailed residential addresses of 342 cases of patients （residents of Heze City） with diaphragm type Budd-Chiari syndrome diagnosed between 1995 and 2004 in Heze Municipal Hospital, Heze Shan County Central Hospital, Affiliated Hospital of Xuzhou Medical College, Shandong Provincial Hospital and Beijing Xuanwu Hospital were collected. Geographic information system （GIS） was used as a platform for data management and display. The nearest neighbor index, Ripley＇s K（d） function, Ripley＇s L（d） function and the nearest neighbor clustering method were applied to detect the spatial characters of Budd-Chiari syndrome in Heze City, Shandong Province. Crimestat 3.0 was used for spatial analysis. Results The nearest neighbor distance analysis showed that the nearest neighbor index was 0.6767 （Z = - 11.4387, P 〈 0.01 ）. That was an aggregation at the first-order spatial scale. Within the study area, the first clustering radius of Budd-Chiari syndrome was 6.66 kin, and the first clustering strength was 5.40; the average radius of the strongest clustering area was 126.61 km, and the clustering strength was 12.52, while the biggest clustering radius was larger than 222 km. After corrected by population, the gathering strength was slightly higher than that before the correction. Ten first-order hot spots were formed, and 95% confidence interval aggregation number was 7, which meant the results were statistically significant（P 〈 0.05 ）, main clustering areas are in Mudan District, Shan County and Juancheng. One second- order hot spot was gathered based on the first-order hot spot. Conclusions Spatial distribution of Budd-Chiari syndrome in Heze City, Shandong Province has showed spatial aggregation and heterogeneity. This study has a great epidemio

关 键 词：布加综合征 空间分布 聚集性 流行病学 

分 类 号：R575[医药卫生—消化系统]