利用磁共振定量测定海马结构体积  

Magnetic Resonance Image-based Hippocampal Formation Volume Measurement

作　　者：周炯[1] 龚小娅[1] 程源深[1] 

机构地区：[1]浙江大学医学院附属第二医院,浙江杭州310003

出　　处：《浙江大学学报（医学版）》2000年第6期257-259,263,共4页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的 :应用磁共振 (MRI)测定颞叶癫痫 (TL E)患者 ,非 TL E患者及正常人的海马结构(HF)体积。讨论该方法在确定 TL E致痫灶中的价值。方法 :用 MRI对 1 3例 TL E患者 ,1 7例非TL E患者及 37例正常人作与脑干长轴平行的倾斜冠状位扫描 ,SE序列 T1加权像 ,测量 HF的体积。采用正常人 HF体积的正常范围及左右两侧 HF体积的差值的正常范围对 TL E患者可能存在的海马硬化进行定位定侧。结果 :正常人 HF的体积范围 :右侧为 1 .95～ 3.6 8cm3,左侧为 1 .93～3.6 1 cm3。TL E组有 7例患者的 HF体积缩小 ,其中 2例为双侧萎缩 ,而非 TL E组无一例 HF体积缩小。结论 :利用 MRI定量测定 HF技术对 TL E患者可能存在的海马萎缩 (HA)的定位定侧有较高的敏感性 ,比目测读片敏感 ,能提高 TL E患者 HA的检出率。Objective:To measure the hippocampal formation (HF) volume in normal subjects and patients with epilepsy,and to evaluate it in lateralization of seizure focus in temporal lobe epilepsy (TLE).Methods:Thirty seven normal subjects and 30 epileptic patients were studied,the latter were subdivided into 2 groups:TLE (13 cases) and non temporal lobe epilepsy (17 ca ses).The volume of HF was measured by SE T 1WI with the imaging plane to the long axis of hippocampus,and the variation of HF volume.The lateralization of TLE was defined by the absolute volumetry value of HF and the normal range of the deviation of bilateral HF volume.Results:The HF volume of normal adults was acquired.Seven patients with TLE and HF volume loss,including 2 bilateral.No patient had volume loss in non temporal lobe epilepsy group.Conclusion:Volumetric measurement of HF by MRI provides higher precision in the estimation of hippocampal size than by visually inspecting a set of MR images.MRI based hippocampal volume measurement is one of the sensitive methods in diagnosing hippocampal sclerosis (HS).This technique can improve the detection rate of HS.

关 键 词：颞叶癫痫 海马 病理学 磁共振成像 

分 类 号：R742.1[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]