复发-缓解型多发性硬化患者初级视觉皮层功能连接的静息态fMRI研究  

fMRI study of functional connectivity of the primary visual cortex（Vl）in relapsing remitting multiple sclerosis during resting state

作　　者：张悦[1] 龚洪翰[1] 周福庆[1] 陈琪[1] 王博[1] 吴麟[1] 

机构地区：[1]南昌大学第一附属医院影像科,江西南昌330006

出　　处：《实用放射学杂志》2013年第11期1723-1726,1761,共5页Journal of Practical Radiology

基　　金：国家自然科学基金资助项目（81060116,81101041）;江西省科技支撑计划资助项目（20111BBG70028-1）.

摘　　要：目的 利用静息态功能磁共振成像技术,观测复发-缓解型多发性硬化（relapsing remitting multiple sclerosis,RRMS）患者初级视觉皮层（V1）与全脑的功能连接.方法 20例RRMS患者与20例年龄及性别匹配的健康志愿者接受静息态功能磁共振成像扫描,选择V1为种子点,分析其与全脑的功能连接,并比较组间差异.结果 RRMS患者右侧顶下小叶（Brodmann＇s area 40,BA40）、右侧额中回（BA46）及右侧小脑与V1的功能连接明显减弱;双侧前扣带回（BA32）与V1的功能连接明显增强.结论 本研究显示静息态RRMS患者V1与广泛的皮质结构的功能连接异常,其改变可能与临床上MS患者常见视空间工作记忆障碍的发生有关.Objective To analyze functional connectivity（FC）of the primary visual cortex（V1 ）using resting-state functional MRI （rs-fMRI）in patients with relapsing remitting multiple sclerosis（RRMS）. Methods 20 patients with RRMS and 20 gender and agematched healthy controls（ HCs）underwent rs-fMRL V1 was selected as region of interest（ROI）and the FC was analyzed between the V1 and the whole brain region, and then interclass difference was described. Results Compared with HCs, decreased FC in the RRMS group between the V1 and the right inferior parietal lobule （Brodmann＇ s area 40, BA40）, the right middle frontal gyrus （BA46）and the right cerebellum. Increased FC was found between V1 and the anterior cingulate gyrus（BA32）. Conclusion Changes in FC of V1 are found in patients with RRMS. It may be related to visual spatial working memory dysfunction.

关 键 词：复发-缓解型多发性硬化 初级视觉皮层 静息态 功能磁共振成像 功能连接 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]