Cavins:胞膜窖相关蛋白新视野  

Cavins: new sights of caveolae-associated protein

作　　者：史丹[1] 刘艳[1] 廉馨[1] 邹伟[1,2] 

机构地区：[1]辽宁师范大学生命科学学院,辽宁大连116081 [2]辽宁省生物技术与分子药物研发重点实验室,辽宁大连116081

出　　处：《生物工程学报》2013年第11期1531-1537,共7页Chinese Journal of Biotechnology

基　　金：国家自然科学基金(Nos.30570225;30970353);辽宁省教育厅重点实验室项目(No.LS2010095);辽宁省教育厅大学生创新项目(No.CSXL201210165007)资助~~

摘　　要：胞膜窖(Caveolae)是细胞膜内陷形成的一种特殊的脂筏结构,含有丰富的胆固醇和鞘磷脂,并在调节细胞信号转导中发挥重要作用。大量的研究显示,caveolae标志蛋白窖蛋白(Caveolins)在维持caveolae的结构及其功能的调节中发挥重要作用。然而,最近研究发现caveolae的形成同样需要另一类蛋白家族Cavins蛋白家族的参与。此外,Cavins蛋白家族成员之一Cavin-1能够与Caveolins主要成员窖蛋白-1(Caveolin-1)相互作用参与调节caveolae的结构和功能。文中将就近年来Cavins与Caveolins的关系及其在调节caveolae中的作用研究进展进行综述。Caveolae are specialized lipid rafts that form flask-shaped invaginations of the plasma membrane. Many researches show that caveolae are involved in cell signaling and transport. Caveolin-1 is the major coat protein essential for the formation of caveolae. Recently, several reports indicated that the other caveolae-associated proteins, Cavins, are required for caveola formation and organization. It＇s worth noting that Cavin-1 could cooperate with Caveolin-I to accommodate the structural integrity and function of caveolae. Here, we reviewed that the relationship between Cavins and Caveolins and explore the role of them in regulating caveolae.

关 键 词：Cavins Cavin-1 窖蛋白-1 胞膜窖 

分 类 号：R363[医药卫生—病理学]