脂肪及细胞因子与非酒精性脂肪性肝病关系的研究进展  

Research progress of new adipocytokines and cytokines in non-alcoholic fatty liver disease

作　　者：刘滨菘[1] 李强[1] 

机构地区：[1]哈尔滨医科大学附属第二医院内分泌代谢病科,哈尔滨医学硕士研究生150086

出　　处：《医学研究生学报》2013年第11期1211-1214,共4页Journal of Medical Postgraduates

基　　金：国家教育部博士学科点科研基金(200802260007)

摘　　要：过去认为脂肪因子是一类由脂肪细胞分泌的细胞因子或激素。研究发现其不仅来自脂肪组织的分泌,也来自于肝。肥胖是非酒精性脂肪性肝病(nonalcoholic fatty liver desease,NAFLD)的独立危险因素之一,而某些脂肪及细胞因子的调节异常会通过一系列的反应使脂肪肝患者体内的脂肪含量增加。现有研究发现,脂肪及细胞因子如视黄醇结合蛋白4(retinol binding protein 4,RBP4)、胎球蛋白-A(fetuin A,FA)、脂肪细胞型脂肪酸结合蛋白(adipocyte fatty acid binding protein,AFABP)、颗粒蛋白前体与NAFLD密切相关,深入了解和研究脂肪及细胞因子与NAFLD的关系有助于NAFLD的有效防治。Adipocytokines were regarded as cytokines or hormone from adipocyte. Researches found that adipoey^kines are likely to be involved in the pathogenesis of nonalcoholic fatty liver desease （NAFLD） since they are secreted not only from adipose tis- sue but also from the liver. Obesity has been identified as one of the risk factors for NAFLD, and dysregulation of adipocytekines and cytokines may represent an important mechanism linking increased fat mass in obesity. Current research found new adipocytokines and cytokines such as retinol binding protein 4 （ RBP4）, fetuin-A, adipocyte fatty acid binding protein and progranulin were closely related with NAFLD. Thorough understanding and studying the adipoeytokines and cytokines in NAFLD can help us prevent and treat NAFLD effectively.

关 键 词：非酒精性脂肪性肝病 视黄醇结合蛋白4 胎球蛋白-A 脂肪细胞型脂肪酸结合蛋白 颗粒蛋白前体 

分 类 号：R575[医药卫生—消化系统]