注意网络功能与左侧额顶环路的经颅磁刺激研究  

Involvement of Left Frontoparietal Pathway in Spatial Attentional Function: Study with Continuous Theta Burst Stimulation

作　　者：徐光青[1] 兰月[2] 赵江莉[1] 陈正宏[1] 何小飞[1] 黄东锋[1] 

机构地区：[1]中山大学附属第一医院康复医学科,广东广州市510080 [2]中山大学附属第三医院康复医学科,广东广州市510630

出　　处：《中国康复理论与实践》2013年第11期1020-1023,共4页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金面上项目(No.81071608;No.81372109);中央高校基本科研业务费专项资金(No.12ykpy38)

摘　　要：目的探讨注意网络功能与左侧额顶环路的关联性。方法健康受试者60人按照性别匹配原则分为顶叶组和额叶组。对左侧背外侧前额叶和后顶叶区进行持续短阵快速脉冲经颅磁刺激后,进行注意网络测试和网络效率评价。结果两组不同提示状态和靶刺激类型的平均反应时均无显著性差异。顶叶组警觉网络效率增强(P<0.05),额叶组警觉网络效率增强(P<0.05),定向网络效率受损(P<0.05)。结论左侧额顶环路神经活动抑制可以提高视空间注意警觉网络效率。Objective To explore the role of left frontoparietal pathway in controlling spatial attentional function. Methods 60 healthy, right-handed humans （30 males and 30 females） aged 18~22 years were recruited. They were divided into frontal group （n=30） and parietal group （n=30） in accordance with sex for either the left dorsolateral prefrontal cortex or the left posterior parietal cortex stimuli study, respec-tively. They were measured with the Attention Network Test following the continuous theta burst stimulation to the left frontoparietal path-way. Results During the Attention Network Test, the efficiencies of alerting network improved in participants after both the left dorsolateral prefrontal cortex and left posterior parietal cortex stimuli. However, the efficiency of orienting network was deficit after the left dorsolateral prefrontal cortex stimuli. Conclusion Inhibition of the left frontoparietal pathway may improve the alerting function of spatial attention net-work.

关 键 词：空间注意网络 额顶环路 持续短阵快速脉冲经颅磁刺激 神经抑制 

分 类 号：R742[医药卫生—神经病学与精神病学]