Advances in Toxicology of Nε-(carboxymethyl)-lysine(CML)  

羧甲基赖氨酸的毒理学研究进展(英文)

作　　者：张振华[1] 孙建霞[2] 白卫滨[1] 欧仕益[1] 邱瑞霞[1] 

机构地区：[1]暨南大学食品科学与工程系,广东广州510632 [2]广东工业大学轻工化工学院,广东广州510090

出　　处：《Agricultural Science & Technology》2013年第10期1403-1408,共6页农业科学与技术（英文版）

基　　金：Supported by "Twelfth Five-Year" National Science and Technology Support Project of China(2012BAK01B03);National 863 Plan(2013AA102202)~~

摘　　要：Advanced glycation end-products （AGEs） are products of non-enzymatic glycation of proteins, lipids or nucleic acids and other macromolecules. To be spe- cific, Nε-（carboxymethyl）-Iysine （CML） is one of the most important components of AGEs, which is wildly distributed in the body and can be formed in vivo or in food processing and heating processes. Previous studies have shown that CML is a ma- jor immunological epitope in AGEs and plays an important role in diabetes and its complications, as well as in the development and progression of aging. This review summarized recent advances in major source, toxicological hazard and control mea- sures of CML.晚期糖基化终末产物(Advanced Glycation End-products,AGEs)是蛋白质、脂质或核酸等大分子物质的非酶糖基化产物。其中,羧甲基赖氨酸(CML)是AGEs的主要结构成分之一,在体内广泛分布,其在生物体内及食品加工和加热过程中均有生成。研究表明,羧甲基赖氨酸(CML)作为AGEs的主要抗原表位,在糖尿病及多种并发症以及衰老的发生发展过程中起着重要作用。该研究对羧甲基赖氨酸(CML)的主要来源、毒理危害以及控制等进展进行综述。

关 键 词：Nε-（carboxymethyl）-Iysine （CML） Source TOXICOLOGY Control 

分 类 号：R114[医药卫生—卫生毒理学]