生长激素强化的肠外营养支持对老年食管癌患者术后机体营养及免疫功能的影响  

Effects of growth hormone enhanced for parenteral nutrition on immune function and nutrition in elderly patients after esophageal cancer surgery

作　　者：许彬东[1] 黄国忠[1] 谢金标[1] 赵金树[1] 陈豪[1] 陈思曾[2] 

机构地区：[1]莆田学院附属医院胸心外科,福建莆田351100 [2]福建医科大学附属第一医院胃肠外科

出　　处：《中华普通外科学文献（电子版）》2013年第5期21-24,共4页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：目的观察生长激素(GH)强化的肠外营养支持对老年食管癌患者术后机体营养及免疫功能的影响。方法筛选食管癌根治性切除术后的患者72例,随机双盲分为试验组28例(生长激素强化静脉营养基础上进行)和对照组44例(单纯静脉营养)。术后分别给予两组患者等氮等热量营养支持10 d,试验组于术后第3天起肠外营养提供生长激素,连用7 d,8 U/d。比较两组手术前后营养和免疫指标变化。结果两组患者术前ALB、TF、IgA、IgG、IgM、CD3+、CD4+、CD4+/CD8+均低于正常值,两组比较差异无统计学意义。术后第6天,试验组ALB、TF、IgA、IgG、IgM、CD3+、CD4+、CD4+/CD8+均高于对照组,CD8+低于对照组,但差异无统计学意义。术后第10天,试验组ALB、TF、IgA、IgG、CD4+/CD8+均显著高于对照组(均P<0.05),IgM高于对照组,但差异无统计学意义。结论生长激素强化的肠外营养支持能有效改善老年食管癌患者术后蛋白代谢及免疫功能。Objective To determine the effects of growth hormone （GH） enriched parenteral nutrition（PN） on nutrition status and immune function in elderly patients after esophageal cancer surgery. Methods Seventy-two esophageal cancer patients who underwent the same elective operation were randomized into 2 groups. Both groups were treated with equal calorie and equal nitrogen by central vein during the immediate 10 days after operation. GH enriched PN group was given GH from the 3rd day after operation, and daily dose was 8 U for seven days. The status of immunological parameters and nutrition parameters were observed and analyzed. Results Before the operation, the levels of ALB, TF, IgA, IgG, IgM, CD3＋, CD4＋, CD4~/CD8＋ of the two groups were less than those of the lower limit of normal value. On the sixth day after operation, all indicators of GH group were better than those of the routine group except of CD8＋ . On the tenth day, the status of ALB, TF, IgA, IgG, CD4＋/CD8~ of GH group was better than those of the routine group （P 〈 0.05）. Conclusion Compared with routine PN, the immune response and nutrition status of elderly patients after esophageal cancer surgery can be ameliorated by GH enhanced PN.

关 键 词：生长激素 肠外营养 食管癌 

分 类 号：R735.1[医药卫生—肿瘤]