程序性细胞死亡因子4与人脑星形细胞肿瘤侵袭性的相关性研究  

Studies on the relationship of PDCD4 with the invasion of astrocytic gliomas

作　　者：万志先[1] 王雄伟[1] 董元训[1] 汪雷[1] 田春雷[1] 王旭光[1] 

机构地区：[1]三峡大学第一临床医学院神经外科,湖北宜昌443003

出　　处：《重庆医学》2013年第32期3900-3901,共2页Chongqing medicine

摘　　要：目的探讨抑癌基因程序性细胞死亡因子4(PDCD4)在脑星形细胞肿瘤中的表达与肿瘤侵袭性的相关性。方法用免疫组化检测PDCD4在脑星形细胞肿瘤中的表达情况,同时通过测量核磁共振影像上的瘤周水肿低信号范围,并与免疫组化表达结果作比较分析。结果在星形细胞肿瘤中随着肿瘤的恶性程度的增加,PDCD4表达下调;肿瘤恶性程度与肿瘤侵袭性指标MRI扫描图像上表现的瘤周水肿低信号范围分级呈正相关(P<0.05),而PDCD4表达与肿瘤侵袭性指标MRI扫描图像上瘤周水肿低信号范围分级呈负相关(P<0.01)。结论 PDCD4可以作为脑星形细胞肿瘤的预后判断指标和侵袭指标之一。Objective To investigate the relationship of programmed cell death 4（PDCD4） with the invasion of astrocytic glio- mas. Methods Using the immunohistochemical, method to detect the expression of PDCD4 in astrocytic gliomas in different grades. Measuring the peritumoral low-density area on MRI scan,then compared with the results of immunohistochemical expression. Re- sults The downregulation of PDCD4 was with the increasing of the malignant grade of astrocytic gliomas. The tumor grade malig nancy was positively correlated with the grade of the peritumoral low-density area on MRI scan（P〈0.05） ,while the expression of PDCD4 was negatively correlated with the grade of astrocytic gliomas（P〈0.01）. Conclusion PDCD4 might serve as one of the in- dicators of invasion and malignant phenotype for astrocytic gliomas.

关 键 词：星形细胞瘤 程序性细胞死亡因子4 侵袭性 

分 类 号：R739.4[医药卫生—肿瘤]