人乳头瘤病毒亚型流行情况调查指导疫苗的开发和引进  

Epidemiology investigation on human papillomavirus subtypes for the exploitation and introduction of vaccine

作　　者：朱新兴 李学军[2] 杨长春[2] 杨红起[2] 赵辉[2] 

机构地区：[1]东营市人民医院,山东东营257091 [2]胜利油田中心医院

出　　处：《现代预防医学》2013年第23期4425-4427,共3页Modern Preventive Medicine

摘　　要：目的明确东营市HPV疫情的分布。对疫苗的开发和引进进行指导。方法采用基因导流杂交技术，对5334名健康体检妇女宫颈脱落细胞中的21种HPV亚型进行检测，对人群感染率、各HPV亚型分布及各年龄段HPV感染率等指标进行统计分析。结果在5334例样本中，HPV总感染率为15．05％（803／5334）；各HPV亚型感染率前4位依次是HPV-16、52、58、53型，占到总感染株的59．38％（566／953）；≤30岁年龄段HPV感染率20．83％显著高于31—40岁（15．27％）、41～50岁（14．34％）和≥51岁（16．15％）年龄段的感染率（P〈0．01）。结论各地区应根据当地HPV亚型的流行情况有针对性的开发引进HPV疫苗，就东营市而言，可针对青春期和青春前期女性开发引进以HPV-16、52、58、53亚型为主的HPV预防性疫苗。OBJECTIVE To guide the exploitation and introduction of vaccine through determining the epidemiological condi- tion of human papillomavirus （HPV） subtypes. METHODS Total of 21 sttbtypes of HPV were detected by polymerase chain reaction and molecular hybridization in cervical exfoliated cells for 5 334 healthy females, and infection rates of all the cases, each subtype of HPV and different ages of females were calculated and analyzed. RESULTS Among all 5 334 cases, the total infection rate of HPV was 15.05% （803/5 334） . Four subtypes of 16, 52, 58 and 53 had the maximum infection rates in turn, which accounted for a total of 59.38% （566/953） in all HPV subtypes.The infection rate of ≤30 age group （20.83%） was significantly higher than that of 31 -40 age group （ 15.27% ） , 41 ~50 age group （ 14.34% ） and 351 age group （16.15%） （P 〈 0.01 ）. CONCLUSION Different areas should exploit and introduce HPV vaccine according to the epidemiolo- gy of HPV subtypes. In Dongying, we should exploit and introduce preventive vaccines of 16, 52, 58 and 53 subtypes for adolescent and preadolescent females.

关 键 词：人乳头瘤病毒 亚型 流行病学 疫苗 

分 类 号：R737.33[医药卫生—肿瘤]