胃癌IMP3和GST-π的表达及其与临床病理特征的关系  

Expressions of IMP3 and GST-π in gastric carcinoma and their relationships with clinical characteristics

作　　者：徐艳娟[1] 许海刚[1] 徐燕玲[1] 吴春林[1] 

机构地区：[1]福建医科大学附属第二医院病理科,福建泉州362000

出　　处：《中国校医》2013年第11期839-841,843,F0003,共5页Chinese Journal of School Doctor

摘　　要：目的探讨IMP3及GST-π在胃癌组织中的表达及意义。方法应用免疫组织化学方法检测49例胃癌及其癌旁正常黏膜组织中IMP3和GST-π的表达。结果 (1)胃癌中IMP3的阳性表达率为81.63%(40/49),其中(+)18例、(++)14例、(+++)8例,IMP3的表达与胃癌组织学分型有关,差异有统计学意义(P<0.01);GST-π的阳性表达率为89.79%(44/49),其中(+)8例、(++)18例、(+++)18例。GST-π在胃癌组织学分型中的表达差异也有统计学意义(P<0.01),并且肠型表达较强。IMP3和GST-π表达在胃癌患者的年龄、性别、淋巴结有无转移和临床分期等方面的差异均无统计学意义(P>0.05)。(2)Spearman等级相关分析显示胃癌中IMP3和GST-π的表达无明显相关性(P>0.05)。(3)癌旁组织中,IMP3和GST-π不表达或仅弱表达,与癌组织相比差异均有统计学意义(P<0.01)。结论 IMP3在胃癌的发生中可能起到一定的作用,并影响胃癌的分型;多耐药基因GST-π在肠型中高表达,提示高分化胃癌更易产生耐药。Objective ＂To explore the expressions of IMP3 and GST-π in gastric carcinoma and their relationships with clinical characteristics. Methods The immunohistochemistry method was used to detect the expression levels of IMP3 and GST-π in tumor tissues and adjacent normal gastric mucosa of 49 gastric carcinoma patients. Results （1） The positive expression rate of IMP3 in gastric carcinoma was 81.63% （40/49） with [（ ＋ ） 18, （ ＋ ＋ ） 14, （ ＋ ＋ ＋ ） 8], and the IMP3 expression was correlated with the histological type of tumor （ P〈 0.01 ）. The positive expression rate of GST-n was 89.79% （44/49）, with [（ ＋ ） 8, （ ＋ ＋ ） 18, （ ＋ ＋ ＋ ） 18], and the GST-r~ expression was also correlated with the histological type of tumor （ P 〈 0.01 ） and the expression level in intestinal type gastric cancer was significantly up-regulated. There was no correlation between the expressions of IMP3 and GST-Trand age, sex, lymph node metastasis, and clinical stage separately （P 〉 0.05 ）. （2） The Spearman Correlation analysis showed there was no correlation between the expressions of IMP3 and GST-π in gastric carcinoma （P 〉 0.05 ）. （3） The weak or negative expression was presented in the adjacent normal gastric mucosa, and compared with the cancerous tissue, the differences had a statistical significance （P〈 0.01）. Conclusions IMP3 may play a role in the occurrence of gastric carcinoma, and affect the stomach cancer classification; The high expression of multiple drug-resistant gene GST-π in intestinal type may indicate high differentiation gastric cancer is more likely to produce drug resistance.

关 键 词：胃肿瘤 IMP3蛋白 人 谷胱甘肽转移酶pi 

分 类 号：R734.2[医药卫生—肿瘤]