慢性肝病患者sCR1与血清透明质酸含量变化的关系研究  

Relationship between the changes of serum levels of soluble complement receptor type 1 and HA in patients with chronic liver disease

作　　者：李守勇[1] 张婷兰[1] 孙阳[1] 

机构地区：[1]山东省枣庄市立医院检验科,277101

出　　处：《中国实用医刊》2013年第23期84-86,共3页Chinese Journal of Practical Medicine

摘　　要：目的研究慢性肝病血清中可溶性Ⅰ型补体受体（sCR1）的浓度变化和透明质酸的含量变化，并分析二者的相关性，以探讨其临床意义。方法采用双抗体夹心ELISA法测定血清中sCR1浓度，采用放射免疫法测定血清透明质酸含量。结果对慢性肝患者群及正常人群进行研究表明，不同肝病患者血清sCR1水平不同程度的升高，慢性肝病血清sCR1含量（O．79±0．20）显著高于正常人群（0．51±0．24）（P〈0．01）；并且22例肝硬化患者血清sCR1含量显著高于慢性肝患者群（P〈0．01）；血清sCR1与透明质酸（HA）二者密切相关（r=0．83）。结论慢性肝病血清sCR1的变化、透明质酸含量的变化与肝脏损伤严重程度密切相关，可为慢性肝病患者的早期、快速、准确诊断提供相应的理论依据。Objective To study the relationship between the changes of serum levels of soluble complement receptor type 1 （sCR1） and HA in patients with chronic liver disease, and investigate the significance of sCR1 and HA. Methods Enzyme-linked immunosorbent assay （ELISA） was used in de-tecting the serum levels of sCR1 , and radioimmuassay was used in detecting the serum levels of HA. Re-sults The results showed that the serum levels of sCR1 in patients with chronic liver disease （0. 79 ± 0. 20, t =2. 1 ） were significantly higher（P 〈0.01 ） than those in healthy individuals （0. 51 ± 0. 24）. The serum levels of sCR1 in 22 hepatocirrhosis patients were significantly higher than those in patients with chronic liver disease （ P 〈 0. 01 ） and correlation with HA （ r = 0. 83 ）. Conclusions The serum levels of sCR1 and HA accumulates in patients with chronic liver disease are closely related with the se-verity of liver injury, and it can provide a theoretical basis for early, rapid and accurate tients with chronic liver disease. diagnosis of pa-tients with chronic liver disease.

关 键 词：慢性肝病 可溶性Ⅰ型补体受体 透明质酸 

分 类 号：R575[医药卫生—消化系统]