GP方案联合全肺放疗治疗鼻咽癌肺转移疗效观察  

Clinical efficacy of whole-lung radiotherapy combined with the project of gemcitabine add cisplatin(GP) for pulmonary metastasis of nasopharyngeal carcinoma.

作　　者：唐爽[1] 李素芳[1] 钟声学[1] 林灿洁 文小芝 陈扬生 

机构地区：[1]广西科技大学第二附属医院放疗科,广西柳州545006

出　　处：《海南医学》2013年第22期3382-3383,共2页Hainan Medical Journal

摘　　要：目的 观察GP方案联合全肺放疗治疗鼻咽癌肺转移的近期疗效及毒性.方法 采用GP方案治疗22例晚期鼻咽癌,男性15例,女性7例;中位年龄54岁;全部病例均有肺转移;合并其他部位转移13例,先行吉西他滨静脉滴注,第1、8天各一次;顺铂第1天静脉滴注;21d为一个周期;两个周期后再行全肺放疗,剂量18～20 Gy.结果 22例患者中CR4例,PR 13例,总有效率为77.3％,主要毒副反应是骨髓抑制、消化道反应等,经对症处理后能顺利完成治疗.结论 GP方案联合全肺放疗治疗鼻咽癌肺转移近期疗效好,毒副反应均可耐受.Objective To explore the efficacy of the whole-lung radiotherapy combined with the project of gemcitabine add cisplatin （GP） for pulmonary metastasis of nasopharyngeal carcinoma.Methods Twenty-two patients （15 males and 7 females,averagely aged 54 years old） were preformed with the whole-lung radiotherapy combined with the project of GP to cure advanced stage nasopharyngeal carcinoma.All the patients had pulmonary metastasis,and 13 patients were complicated with other locus metastasis.Gemcitabine was dripped intravenously on the 1gt and 8th day,and DDP was used on the first day,with a cycle time of 21 days.18～22 GY dosage whole-lung radiotherapy was employed after two cycles.Results In the 22 cases,4 cases showed complete response （CR） and 13 showedpartial response （PR）,with the total effective rate of 77.2%.The main adverse reactions were myelosuppression,enteron reaction,which can be cured by cooresponding treatment.Conclusion The whole-lung radiotherapy combined with the project of GP is effective to cure pulmonary metastasis of nasopharyngeal carcinoma in the near future,with tolerable adverse reactions.

关 键 词：吉西他滨 鼻咽癌肺转移 化疗 全肺放疗 

分 类 号：R739.63[医药卫生—肿瘤]