急性白血病患者化疗前后血清IGF-Ⅱ、IL-8和VEGF检测的临床意义  

Clinical Significance of Estimation the Changes on Serum IGF-Ⅱ,IL-8 and VEGF Levels After Chemotherapy in Patients with Acute Leukemia

作　　者：胡娟[1] 周彦[1] 温江涛[1] 王茁[1] 

机构地区：[1]江苏省连云港市第二人民医院,222000

出　　处：《放射免疫学杂志》2013年第6期725-727,共3页Journal of Radioimmanology

摘　　要：目的:探讨急性白血病患者化疗前后血清IGF-Ⅱ、IL-8和VEGF水平的变化及临床意义。方法:应用放射免疫分析和酶联法对31例急性白血病患者进行了血清IGF-Ⅱ、IL-8和VEGF检测,并与35名正常健康人作比较。结果:急性白血病患者在化疗前血清IGF-Ⅱ、IL-8和VEGF水平均非常显著地高于正常人组(P<0.01),化疗后6个月未复发者28例,明显下降接近正常人组,而复发的3例其数值又回升到化疗前水平(P<0.01)。结论:检测急性白血病患者血清IGF-Ⅱ、IL-8和VEGF水平的变化可作为诊断和疗效观察的参数。Objective To explore the clinical significance of changes on serum IGF-Ⅱ, IL-8 and VEGF levels after chemotherapy in patients with acute leukemia. Methods Serum IGF-Ⅱ, IL-8（with RIA） and VEGF（with ELISA） levels detemined in 31 patients with a- cute leukemia both before and after chemotherapy as well as in 35 normal healthy controls. Results Before chemotherapy, serum IGF-Ⅱ, IL-8 and VEGF levels in the patients proved significantly higher than those in controls（P 〈0.01 ）. 6 months after chemotherapy the levels in 28 patients without recurrence dropped markedly and approached those in controls. However, in the 3 cases with recurrence, the levels after return again approaching those before chemotherapy （P 〈 0.01 ）. Conclusion The changeful serum levels of IGF-Ⅱ, IL-8 and VEGF might be useful as indicative parameters for diagnosis and curative effect in patients with acute leukemia.

关 键 词：急性白血病 胰岛素样生长因子-Ⅱ 白细胞介素-8血管内皮生长因子 

分 类 号：R733.710.7[医药卫生—肿瘤]