长期低铅染毒大鼠脾脏超微结构的观察  

Ultrastructure of splenic immune cell in rats with long term low level lead exposure

作　　者：刘倩琦[1] 陈荣华[1] 秦锐[2] 张健宁[3] 

机构地区：[1]南京医科大学儿科系,南京210029 [2]南京医科大学第二附属医院江苏省儿童保健研究中心,南京210029 [3]南京医科大学电镜室,南京210029

出　　处：《电子显微学报》2000年第6期824-828,共5页Journal of Chinese Electron Microscopy Society

摘　　要：目的 :探讨长期低铅染毒对大鼠脾脏免疫细胞超微结构的影响。方法 :建立低铅染毒的大鼠模型 ,8周后测定血铅并应用透射电镜技术观察大鼠脾脏免疫细胞的超微结构。结果 :1电镜观察 ,脾脏免疫细胞出现不同程度的线粒体肿胀、空泡化或固缩 ;内质网肿胀、脱颗粒 ;2以上变化均随着铅染毒剂量的增加而加重。结论 :长期低铅染毒即可导致脾脏免疫细胞的损伤 。Objective:To study the effects of long term low level lead exposure on ultrastructure of splenic immune cell in rats. Methods:The young SD rats were divided into six groups and fed with standard diet and low level lead diet for 8 weeks. After the experiment, the blood lead was measured and the ultrastructure of splenic immune cell was observed by transmission electron microscope. Results:Electron micrographs of splenic immune cell indicated that mitochondria were swollen, vaculated and pyknotic and endoplasmic reticular were swollen and degranulated. Conclusion:The long term low level lead exposure could cause the functions of splenic immune cell to be impaired. These would provide a morphologic basis for further studying immunotoxicity of lead .

关 键 词：醋酸铅 大鼠 脾脏 透射电镜 超微结构 染毒 

分 类 号：R361.3[医药卫生—病理学]