老年废用性骨质疏松症的发病机制探讨  

Exploration of Pathogenesis of Elder Disuse Osteoporosis

作　　者：吴晨[1] 谢吟灵[1] 史晓[1] 

机构地区：[1]上海中医药大学附属岳阳中西医结合医院老年科,上海200437

出　　处：《医学综述》2013年第22期4148-4150,共3页Medical Recapitulate

摘　　要：老年人骨质疏松症与增龄性骨组织退化及废用性骨量减少有关。老年人骨折后、偏瘫、肢体或脊柱神经损伤或危重手术后会造成患者长期卧床,患肢肌力负荷减弱,骨骼肌萎缩,骨量严重流失,骨质疏松加重。该文尝试从机械外力作用、神经因子及递质减少、内分泌及细胞因子改变等方面探讨废用性骨质疏松症的发病机制。The pathogenesis of elder osteoporosis is related to aging bone tissue degradation and disuse osteopenia. After senile fracture, hemiplegia, nerve injury or operation, long-term bed rest may lead limb muscle strength decrease and serious loss of bone mass, and aggravated osteoporosis. Here attempts to explore the pathogenesis of elder disuse osteoporosis from the perspectives of function of the muscle mechanic, reduc- tion of the neurotrophic factor and neurotransmitter,and changes of endocrine and cytokine.

关 键 词：老年废用性骨质疏松 机械外力 神经因子 骨代谢 

分 类 号：R58[医药卫生—内分泌]