肠道菌群对慢性肝脏疾病影响的研究进展  

Research progress on effect of intestinal flora on chronic liver diseases

作　　者：吴夏飞[1,2] 连娜琦 陆春风[1,2] 张峰[1,2] 陆茵[1,2] 郑仕中[1,2,3] 

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]南京中医药大学中药学一级学科,江苏南京210023 [3]南京中医药大学江苏省中药药效与安全性评价重点实验室,江苏南京210023

出　　处：《中国药理学通报》2013年第12期1644-1647,共4页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81270514;30873424);教育部博士点基金(No 20103237110010);江苏省自然科学基金资助项目(No BK2008456);江苏省六大人才基金(No 2009-B-010);江苏省针灸学重点实验室开放课题(No KJA200801);江苏高校优势学科建设工程资助项目(No ysxk-2010);南京中医药大学中药学一级学科开放课题资助(No 2011ZYX4-008);"十一五"科技支撑计划(No 2008BAI51B02)

摘　　要：慢性肝脏疾病与肠道菌群的改变息息相关。越来越多的研究表明,肠道菌群的变化在肝脏炎症反应过程中发挥关键作用。肠道微生物的产生能够激活体内免疫系统,导致促炎症基因的表达,进而促进慢性肝脏疾病的发生,其中包括病毒性肝炎、酒精性肝病、非酒精性脂肪性肝病、肝硬化等。其并发症有全身性菌血症、肝性脑病、自发性细菌性腹膜炎及肾功能衰竭,已严重威胁到人类的健康。因此,肠道菌群的改变与慢性肝脏疾病之间的关系受到广泛关注,改善肠道微生态系统已经成为治疗慢性肝病的重要手段。Chronic liver diseases are closely related to the chan- ges of intestinal flora. More and more studies have showed that the changes of intestinal flora play a key role in liver inflammato- ry reaction process. The production of intestinal microflora can activate the immune system,leading to the expression of proin- flammation gene, and then promoting liver inflammation, inclu- ding viral hepatitis, alcoholic liver diseases, non-alcoholic fatty liver diseases, cirrhosis, and so on. The complications which have been serious threat to human health include systemic bacte-remia, hepatic encephalopathy, spontaneous bacteremia perito- nitis and renal failure. Therefore, the relationship between chan- ges of intestinal flora and chronic liver diseases has received extensive attention, and improving intestinal micro ecology system has become the main means of the treatment of chronic liver diseases.

关 键 词：肠道菌群 慢性肝病 细菌易位 内毒素 肝炎 肝硬化 

分 类 号：R-05[医药卫生] R322.45