200例原发性肝癌的临床特征分析  

Clinical Characteristics Analysis of 200 Cases of Primary Liver Cancer

作　　者：李青[1] 史为涛[2] 王勤英[2] 

机构地区：[1]山西医科大学太原市第三人民医院,山西太原030012 [2]山西医科大学附属第一医院感染科,山西太原030001

出　　处：《中国医药指南》2013年第31期42-44,共3页Guide of China Medicine

摘　　要：目的探讨太原地区原发性肝癌（PHC）的临床特征及相关病因，提高人们对该病的认识，为有效防控该病提供科学依据。方法回顾分析我院200例PHC患者的完整资料，对其年龄、性别、首发症状、相关病因、乙型肝炎病毒（HBV）标志物等，临床资料进行分析。结果①200例患者中，男女比例3．5：1；年龄分布为24～88（58．10±11．42）岁，高发年龄阶段为50～60岁，发患者数占38％；②首发症状缺乏特异性，主要以腹部不适、憋胀或腹痛为主；③PHC患者中75％有HBV感染史，63％合并肝硬化；④PHC患者中，HBeAg阴性的患者多于HBeAg阳性的患者，并且HBV感染主要以“HBsAg（＋）、抗．HBe（＋）、抗-HBc（＋）”为主，占36．5％（73／200）；⑤HBV感染者中HBVDNA阳性率62％（93／150），HBV-DNA载量多在105copies／mL以下。结论HCC患者多为男性，50-60岁为高发年龄段，首发症状缺乏特异性，大多有乙肝后肝硬化病史，感染模式以HBsAg、抗-HBe和抗-HBc三项阳性为主，且HBV-DNA载量多左105cooies／mL。Objective To Explore the Taiyuan area primary hepatocellular carcinoma （PHC） and related etiology clinical features, improve awareness of the disease, in order to provide the scientific basis for effective prevention and control of disease. Methods Retrospective analysis of patients in our hospital 200 cases of PHC complete information on its age, sex, initial symptoms, underlying causes, hepatitis B virus （HBV） markers and other clinical data were analyzed. Results ①two hundreds of patients, the male to female ratio 3.5：1; age distribution of 24-88 （58.10±11.42） years, high ages 50 to 60 years, the incidence accounted for 38%; ②the first symptom of the lack of specificity resistance, mainly abdominal discomfort, abdominal pain or swelling choke; ③ about 75% of PHC patients have HBV infection, 63% of them have cirrhosis Simultaneously; ④PHC patients, HBeAg-negative patients than in HBeAg- positive patients and HBV infection mainly ＂HBsAg （＋）, anti-HBe （＋）, anti-HBc （＋）＂, accounting for 36.5% （73/200）; ⑤HBV infection in HBV DNA positive rate was 62% （93/150）, HBV-DNA load more in 105copies/ml less. Conclusion PHC patients are mainly male, 50 to 60 years for the high age, the first symptom of the lack of specificity, and most had a history of liver cirrosis, infection mode for HBsAg, anti-HBe and anti-HBc positive based, and HBV- DNA load more in 105 copies/ml less.

关 键 词：原发性肝癌 肝硬化 乙型肝炎病毒 HBV DNA 

分 类 号：R735.7[医药卫生—肿瘤]