还原型谷胱甘肽在检疫期新兵3000米体能训练中的肾脏保护作用  

Protection of Kidney of Reduced Glutathione on Recruits in Quarantine Period in 3000m Physical Training

作　　者：周刊[1] 方如美[1] 刘志昂[2] 陈伯成[1] 农永丽[1] 

机构地区：[1]解放军303医院肾内科,广西南宁530023 [2]解放军303医院检验科,广西南宁530023

出　　处：《华南国防医学杂志》2013年第10期745-746,762,共3页Military Medical Journal of South China

基　　金：广西卫生厅自筹基金课题(Z2010465)

摘　　要：目的探讨还原型谷胱甘肽(reduced glutathione,GSH)在检疫期新兵3000米体能训练中保护肾脏的临床观察。方法将100名检疫期新兵随机分为服GSH组和对照组,观察两组训练前后血清β2微球蛋白(beta 2 microglobulin,β2-MG)、乳酸脱氢酶(lactate dehydrogenase,LDH)、肌酸激酶(creatine kinase,CK)、α-羟丁酸脱氢酶(α-hydroxybutyrate dehydrogenase,α-HBD)、血尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,Scr)、超氧化物歧化酶(super oxide dismutase,SOD)及尿液改变,并对结果进行统计学分析。结果 GSH组在提升SOD水平、降低酶学指标、降低尿蛋白和尿隐血阳性率上优于对照组(P<0.05)。结论GSH能够提高机体抗氧化能力、减轻训练后急性肾损伤,对提高部队战斗力具有积极意义。Objective To explore the kidney protection effect of reduced glutathione （GSH） on recruits in quaran tine period in 3000m physical training. Methods A total of 100 recruits in quarantine period were randomly divided into GSH group and control group. Serum β2microglobulin （β2MG）, lactate dehydrogenase （LDH）, creatine kinase （CK）, ahydroxybutyrate dehydrogenase （HBD）, blood urea nitrogen （BUN）, serum ereatinine （Scr）, superoxide dismutase （SOD） and urine changes were observed before and after training. Results GSH group was priori than control group in increasing SOD levels, reducing enzymatic indicators, reducing the positive rate of urinary protein and urine occult blood （P〈0. 05）. Conclusion GSH can increase the antioxidant capacity and relieve the acute kidney injury after training, which is significant to improve the combat ability of the troops.

关 键 词：还原型谷胱甘肽 氧自由基 3000米体能训练 急性肾损伤 

分 类 号：R743.33[医药卫生—神经病学与精神病学]