乳腺癌合并2型糖尿病患者的临床病理特征及预后影响因素分析  

Clinicopathologic Features and Influence Factors of Prognosis in Breast Cancer Patients Complicated with Type-2 Diabetes Mellitus

作　　者：智亮辉[1] 王少文[1] 易小龙 侯会池[1] 刘伟[1] 

机构地区：[1]北京军区白求恩国际和平医院普外一科,石家庄050082 [2]阳谷县人民医院普通外科,山东阳谷252300

出　　处：《解放军医药杂志》2013年第11期56-58,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨乳腺癌合并2型糖尿病(T2DM)患者的临床病理特征及预后影响因素,为此类患者的个体化治疗提供依据。方法对解放军白求恩国际和平医院2005年1月—2007年12月收治的136例乳腺癌按是否合并T2DM分为合并T2DM组(n=49)及非合并T2DM组(n=87),对两组的临床病理资料及无病生存情况进行统计学分析。结果两组雌激素受体状况及淋巴结转移差异有统计学意义(P<0.05);合并T2DM组复发转移率(29%)高于非合并T2DM组(14%),无病生存率低于非合并T2DM组(P<0.05);Cox比例风险模型的预后分析显示,合并T2DM、淋巴结转移及雌激素受体状态是乳腺癌患者预后的独立危险因素(P<0.01,P<0.05)。结论 2型糖尿病是乳腺癌患者复发和转移的独立危险因素,合并T2DM的乳腺癌患者需要更合理的治疗方式。Objective To explore clinicopathologic features and influence factors in breast cancer patients com- plicated with type 2 diabetes mellitus （T2DM） in order to provide guidance for individualized treatment. Methods A total of 136 patients with breast cancer during January 2005 and December 2007 in Bethune International Peace Hospital of PLA were divided into T2DM combination group （group A, n = 49） and non-T2DM combination group （group B, n = 87） according to whether the patients were complicated with T2DM or not, and clinicopathologic data and disease-free survival condition were statistically analyzed. Results The differences in estrogen receptor （ER） and lymph nodes me- tastasis in the two groups were statistically significant （P 〈 0. 05 ） ; the recurrent metastasis rate was 29% in group A and was significantly higher than 14% in group B, and disease free survival was significantly lower than that in group B （ P 〈 0.05） ; independent risk factors in prognosis for patients with breast cancer were complication of T2DM, lymph nodes metastasis and ER expression by analyzing with Cox proportional hazards model （ P 〈 0.01, P 〈 0.05 ）. Conclusion T2DM is an independent factor for patients with breast cancer, therefore breast cancer patients complicated with T2DM need more appropriate treatment.

关 键 词：乳腺肿瘤 糖尿病 2型 临床病理特征 预后 

分 类 号：R737.9[医药卫生—肿瘤]