转移性结直肠癌的维持治疗  

Maintenance treatment of metastatic colorectal cancer

作　　者：蒙燕[1] 杨建伟[2] 

机构地区：[1]福建中医药大学第二临床医学院,福州350122 [2]福建省肿瘤医院消化内科,福州350014

出　　处：《国际病理科学与临床杂志》2013年第5期412-415,共4页Journal of International Pathology and Clinical Medicine

摘　　要：转移性结直肠癌治疗已从单纯化学药物治疗向与分子靶向药物联合的方向转化,传统持续给药至疾病进展或患者不能耐受的维持治疗策略也受到许多新策略的挑战。维持治疗不仅可以巩固一线治疗的疗效,而且可以减轻化学治疗药物的累积性毒性,有效提高患者生活质量,延缓疾病进展,并最终延长总生存期。维持治疗已成为转移性结直肠癌化学治疗的研究热点。Treatment for metastatic colorectal cancer has transferred simple chemotherapy to targeted combination therapy. The traditional maintenance treatment, which keep medication for patients till progress has been made or till patients could not tolerate the treatment-related toxicity, has been challenged by some new therapy strategies. Maintenance treatment dose not only consolidate the efficacy of first-line treatment, but also reduce the cumulative toxicity of chemotherapy. It can effectively improve the patients＇ quality of life, slow down disease progression, and eventually prolong overall survival. Maintenance treatment has become a research focus on metastatic colorectal cancer chemotherapy.

关 键 词：转移性结直肠癌 维持治疗 化学治疗 靶向治疗 

分 类 号：R735.3[医药卫生—肿瘤]