酪氨酸羟化酶的研究进展  

Progress in study on tyrosine hydroxylase

作　　者：张赫楠[1] 李平[2] 白芳芳[2] 李家立[2] 马洪浩[2] 

机构地区：[1]中国中医科学院广安门医院心内科,北京100053 [2]北京中医药大学第三附属医院心内科,北京100029

出　　处：《国际病理科学与临床杂志》2013年第5期449-452,共4页Journal of International Pathology and Clinical Medicine

基　　金：十一五国家科技支撑计划项目(2007BAI10B02-07)~~

摘　　要：人体内重要的神经递质儿茶酚胺由酪氨酸合成而来,此过程中四种酶以不同方式参与儿茶酚胺合成。酪氨酸羟化酶是此过程第一个酶,既是限速酶,同时也起到催化的作用,其检测为阳性的部位可代表交感神经的分布。最近研究认为,心律失常发生增加的主要可能机制之一为心脏交感重构。神经纤维增多导致儿茶酚胺释放增多,交感神经活性增加,与副交感神经支配不均衡。因此,检测心律失常的患者心肌中酪氨酸羟化酶的阳性分布特征,可以证实交感重构是否可以作为心律失常的主要发生原因。Catecholamine, an important neurotransmitter, is derived from tyrosine synthesis and four enzymes are involved in the synthesis process. Tyrosine hydroxylase is the first reported enzyme in tyrosine synthesis, which serves as the speed limit enzymes and plays a role in catalyst, The positive staining of immunohistochemistry indicates the sympathetic nerve distribution. Latest studies suggest that the increased incidence of arrhythmia is closely related to sympathetic reconstruction in the heart. The increase in nerve fibers leads to an elevated catecholamine level and sympathetic activity, resulting in imbalance of parasympathetic activity. Therefore, the detection of positive distribution of tyrosine hydroxylase in patients with cardiac arrhythmias can help to make a iudgement whether the sympathetic reconstruction plays a major role in the occurrence of arrhythmia.

关 键 词：酪氨酸羟化酶 儿茶酚胺 标志物 交感神经 

分 类 号：R742.5[医药卫生—神经病学与精神病学]