宫颈癌前病变与人乳头状瘤感染的相关性研究  

作　　者：张冰丽[1] 

机构地区：[1]梅州市人民医院妇产科,广东514000

出　　处：《当代医学》2013年第32期65-66,共2页Contemporary Medicine

摘　　要：目的探讨宫颈癌前病变与人乳头状瘤（HPV）感染的相关性。方法对160例研究对象的宫颈采集的标本进行HPV—DNA定量检测和阴道镜检查，对相关数据进行统计分析。结果160例宫颈病变患者中，宫颈炎、CINI、CINII及CINIII分别为29、56、56和39例，CINI、CINII及CINIII患者HPV—DNA阳性率组内比较差异无统计学意义（p〉0．05），与宫颈炎患者比较差异有统计学意义（x^2=105940、50．0550、253042，P〈0．05），CIN患者HPV病毒载量高于宫颈炎患者（t=-121753、291556、194403，P〈0.05），HPV病毒载量随病变严重程度增加而增加。HPV病毒载量在0～0．99、100～999、1000～99．9和100．00～范围内，不同病理类型患者组间比较差异有统计学意义（p〈0．05），随着病变程度加重，HPV病毒载量增加。结论宫颈癌前病变与HPV感染存在着密切的联系，HIV病毒载量与宫颈病蛮的游展有一定关系．Objective To investigate the correlation between cervical precancerous lesion and human papillomavirus （HPV）infection. Methods The cervical specimen of 160 patients were determined by HPV-DNA and colposcopy, the related data was for statistical analysis. Results Among 160 patients with cervical lesions ,there was 29 cases with cervicitis, 36 cases with C1NI, 56 cases with CIN 1I ,and the positive rate of HPV DNA of 39 patients with CINI11 was no statistical significant difference in the same group （P 〉 0.05）, there was statistical significant compared with patients with cervicitis （Z2=10.5940.30.0550.23.3042,P〈0.05）, the HPV viral load of C1N patients exceeded the cervicitis patients （t=-12.1733.29.1556, 19.4403 ,P〈0.05）, HPV viral load increased with the disease severity. HPV viral load was in the scope of 0 -0.99, 1.00-9.99.10.00-99.9 and 100.00-, the patients with different pathological types compared between groups ,there was statistical significant （P〈0.05）, the more exacerbation of pathological changed, HPV viral load increased. Conclusion There is close relation between cervical precancerous lesion and human papillomavirus （HPV）infection, and there is the relationship between HPV viral load and the progress of cervical lesions.

关 键 词：宫颈癌前病变 人乳头状瘤 相关性 

分 类 号：R737.33[医药卫生—肿瘤]