重组葡激酶治疗实验性视网膜中央动脉阻塞  

RECOMBINANT STAPHYLOKINSE IN THE TREATMENT OF EXPERIMENTAL OCCLUSION OF THE CENTRAL RETINAL ARTERY

作　　者：姚勇[1] 蔡季平[2] 周韵秋[2] 王志英[2] 

机构地区：[1]江苏省无锡市第二人民医院眼科,214002 [2]上海第二军医大学长征医院眼科,200003

出　　处：《中国现代医学杂志》2000年第12期22-24,共3页China Journal of Modern Medicine

摘　　要：目的 :观察重组葡激酶 (recombinantstaphylokinase ,r-Sak)治疗实验性视网膜中央动脉阻塞的效果及其对全身的影响。方法 :光化学法建立视网膜中央动脉阻塞模型 ,静注r -Sak、重组链激酶和尿激酶溶栓 ,观察血管再通情况及其对循环系统的影响。结果 :r-Sak的治疗效果明显 ,对全身的影响较小。结论 :r -Sak是一种高效、安全、特异性强的溶栓药 。Objective:To inspect the results of recombinant staphylokinase in the treatment of experimental central retinal artery occlusion,and also to observe the changes of fibrinolytic activity in the systemic circulation.Methods:The animal model was set up by photochemical method and then the thrombus was to be dissolved by intravenous injetion of recombinant staphyloinase(r-Sak),recombinant streptokinase (r-SK) and urokinase (UK).The patency of the artery was evaluated by FFA.Moreover,the changes of fibrinolitic activity in the blood were exmined by phlebotomizing.Results:The market therpeutic effect had been obtained and no significant systemic fibrinolytic activation was observed in r-Sak group.Conclusions:R-Sak is capable of lysing thrombus in retinal artery without significant activation of circulating plasminogen,it may have potential bright future in treatment of occlusion of central retinal artery clinically.

关 键 词：重组葡激酶 重组链激酶 尿激酶 视网膜动脉阻塞 光化学法 

分 类 号：R774.105[医药卫生—眼科]