循环肝癌细胞的研究进展和技术问题  

Research progress and upcoming challenges of circulating tumor cells in hepatocellular carcinoma

作　　者：张妤[1] 杨霞[1] 殷正丰[1] 

机构地区：[1]第二军医大学东方肝胆外科医院分子肿瘤研究室,上海200438

出　　处：《分子诊断与治疗杂志》2013年第6期406-411,共6页Journal of Molecular Diagnostics and Therapy

基　　金：国家传染病重大专项基金(2012ZX10002012-010);国家自然科学基金(81172207;81272669)

摘　　要：复发转移是导致绝大多数肝癌患者术后死亡的主要原因。现有的研究提示,从原发灶或转移灶释放进入血液的循环肿瘤细胞(circulating tumor cells,CTCs)是肝癌根治性术后复发转移的一个主要根源。在过去的10多年中,尽管CTCs检测技术及其临床意义的研究取得了长足进步,但由于缺乏可使用的肝癌CTCs检测方法,目前人们对于肝癌CTCs临床重要性的认识远不及其他主要类型的肿瘤。可喜的是,近年来关于肝癌CTCs检测方法及其临床意义的研究报道逐渐增多,并且得到一些有趣的结果。本文着重总结已报道的肝癌CTCs检测方法,综述肝癌CTCs作为肝癌复发转移来源的现有实验证据以及其作为肝癌预后标志物的现有研究结果,并讨论肝癌CTCs临床转化应用需要解决的技术问题。Recurrence or metastasis is the major cause of mortality in the patients with hepatocellular carcinoma （HCC） who underwent hepatectomy. Circulating tumor cells （CTCs） disseminated from the primary tumor into the peripheral blood are increasingly recognized as the main source of recurrence and metastasis. In the past decade, with the tremendous progress in the technology of CTC detection, there is convincing evidence that CTCs have great potential as a marker for metastatic disease and poor prognosis in patients with a malignancy. However, probably due to the inability of current commercial methods to capture HCC cells, few studies examining CTC counts have been conducted on HCC patients so far, and knowledge about clinical relevance of CTC detection in HCC is lagging behind other major tumor diseases. Fortunately, some interesting and encouraging results have been recently achieved in the HCC CTC detection, and the situation has started to change for HCC. Here we will outline the different approaches available for HCC CTCs, review clinical studies on CTC detection in HCC patients, and formulate upcoming challenges and technical aspects in this field.

关 键 词：肝细胞癌 循环肿瘤细胞 复发与转移 预后 

分 类 号：R735.7[医药卫生—肿瘤]