肿瘤相关巨噬细胞促进肿瘤转移的机制  

The metastasis-promoting roles of tumor-associated macrophages

作　　者：杜胜霖 王艳林[1] 

机构地区：[1]三峡大学医学院,三峡大学分子生物学研究所,湖北宜昌443002

出　　处：《分子诊断与治疗杂志》2013年第6期412-415,共4页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金资助项目(30973445)

摘　　要：浸入肿瘤微环境中的肿瘤相关巨噬细胞在不同因子的刺激下,可分化为具有抗肿瘤功能的M1型巨噬细胞和具有促肿瘤功能的M2型巨噬细胞。在大多数肿瘤中肿瘤相关巨噬细胞以M2型为主,它参与肿瘤新血管形成、基底膜破坏、细胞外基质重塑、肿瘤细胞上皮间质转化等与肿瘤细胞侵袭转移相关的过程,由此肿瘤相关巨噬细胞已经成为肿瘤靶向治疗的重要靶点。本文主要探讨肿瘤相关巨噬细胞与肿瘤细胞的相互作用,以及其在促进肿瘤转移的各个环节中的分子机制。Under the stimulation of different cytokines, tumor-associated macrophages （TAM） immersed into the tumor microenvironment can be differentiated into M1 macrophage with anti-tumor function and M2 macrophage with tumor-promoting function. M2 macrophage is the major type of TAM in the majority of tumors. It is involved in the multiple metastasis-related processes, such as tumor angiogenesis, breakdown of the basement membrane, remodeling of the extracellular matrix and tumor cell＇s epithelial-mesenchymal transition. So that TAM has become an important target for tumor targeting therapy. This article mainly discusses the interaction between TAM and tumor cells and its underlying molecular mechanisms in promoting tumor metastasis.

关 键 词：肿瘤 转移 肿瘤相关巨噬细胞 

分 类 号：R730.2[医药卫生—肿瘤]