卡铂在多壁碳纳米管玻碳电极上的电化学行为及测定的研究  

Study on the Electrochemical Behavior of Carboplatin at Multi-walled Carbon Nanotubes Modified Glassy Carbon Electrode and the Determination of Carboplatin

作　　者：叶丽清[1] 普绍平 放茂良[1] 高云涛[1] 贝玉祥 闫莉莉[1] 

机构地区：[1]云南民族大学化学与生物技术学院,民族药资源化学国家民委-教育部重点实验室,昆明650500 [2]昆明贵研药业有限公司,昆明650106

出　　处：《贵金属》2013年第4期48-52,共5页Precious Metals

基　　金：云南省创新团队计划(2011HC008);云南省高校科技创新团队计划项目(2011UY09)

摘　　要：采用循环伏安法(CV)和差分脉冲伏安法(DPV),研究了卡铂在多壁碳纳米管玻碳电极(MWCNTs/GCE)上的电化学行为并建立了卡铂的测定方法。结果表明:卡铂在多壁碳纳米管玻碳电极上有一对氧化还原峰,氧化峰电位Epa与还原峰电位Epc分别为0.73 V、0.26 V,峰电位之差为?E=0.47 V,Ipa/Ipc=1.57。在优化条件下,卡铂的氧化峰电流与其浓度在0.22～0.67 mmol/L范围内成良好的线性关系(r=0.9942),检出限为0.2 mmol/L。方法操作简便,准确可靠、灵敏度高,可用于卡铂含量的直接测定。The electrochemical behavior of carboplatin at multi-walled carbon nanotubes modified glassy carbon electrode was investigated by cyclic voltammetry and differential pulse voltammetry, and a new method was established for the determination of carboplatin. The results show that one pair of redox peaks of carboplatin with 0.73 V of Epa and 0.26 V of Epc （△E=0.47 V, and Ip/Ipc=1.57） was obtained at multi-walled carbon nanotubes modified glassy carbon electrode by cyclic voltammetry. Under the optimal conditions, the oxidization peak was linearly related to the concentration of carboplatin in the range of 0.22-0.67 mmol/L with the detection limit of 0.2 mmol/L. The method was convenient, accurate, credible and sensitive, and can be used in the determination of carboplatin.

关 键 词：分析化学 卡铂 多壁碳纳米管 电极 电化学行为 伏安法 

分 类 号：O657.1[理学—分析化学]