假尿苷测定对宫颈癌卵巢癌诊断意义的探讨  

The study on the value of measure of pseudouridine in the diagnosis of cervical and ovarian cancer

作　　者：王景萍[1] 李杰[1] 周梦强[2] 周丽莉[1] 王玲 

机构地区：[1]河南省肿瘤研究所,河南郑州450003 [2]河南省肿瘤医院,河南郑州450003

出　　处：《河南医学研究》2000年第4期348-349,共2页Henan Medical Research

基　　金：河南省医科学院科研基金项目。

摘　　要：目的：探讨尿中假尿苷（Ｐｓｅｕｄｏｕｒｉｄｉｎｅ简称 Ψ）含量对宫颈癌、卵巢癌的诊断价值。方法：采用高效液相色谱法（ＨＰＬＣ）同时测定了２３例宫颈癌，１３例卵巢癌病人和２５例正常妇女尿液的假尿苷和肌酐（Ｃｒｅａｔｉｎｉｎｅ简称Ｃｒ）。结果：尿 Ψ／Ｃｒ宫颈癌组为 ３０．６７± ５．５３ ｎｍｏｌ／μｍｏｌ，卵巢癌组为 ３２．６６± ５．０２ ｎｍｏｌ／μｍｏｌ，显著高于正常组 ２０． ２５±３．２２ｎｍｏｌ／μｍｏｌ。结论：测定尿中 Ψ／Ｃｒ对宫颈癌、卵巢癌的诊断及病情判断具有重要价值。Objective: Study the value of measure of pseudouridine(Ψ)in the diagnosis of cervical and ovarian cancer. Methods: With high power liquid chromatograpth(HPLC), the content of pseudouridine and creatinine(Cr) in urine was measured in the patients with cervical and ovarian cancer and nounal women. Results: Ψ/Cr 30. 67± 5. 53 nmol/μmol in cervical cancer group, and 32.66±5. 02 nmol/μmol in ovarian cancer. Compared with normal group20. 25±3. 22 nmol/μmol, Ψ/Cr in cervical and ovarian cancer groups was significantly increased(P < 0. 001). Conclusion: The measure of Ψ/Cr possesses important value on diagnosis and judgement of disease condition in cervical and ovarian cancer.

关 键 词：假尿苷 肌酐 宫颈癌 卵巢癌 高效液相色谱法 

分 类 号：R737.330.4[医药卫生—肿瘤]