利培酮治疗初发精神分裂症的固定剂量与疗效对照研究  

A controlled study of fixed dose of risperidone in treatment of the first episode schizophrenia.

作　　者：陈圣祺[1] 孙明[1] 

机构地区：[1]上海市杨浦区精神卫生中心，200090

出　　处：《四川精神卫生》2000年第4期238-239,共2页Sichuan Mental Health

摘　　要：探讨利培酮治疗初发精神分裂症固定剂量与临床疗效关系。方法　将初发精神分裂症患者 5 2例随机分为固定剂量组 (A组 )和常规剂量组 (B组 ) ,采用利培酮治疗 12周 ,并以简明精神病评定量表 (BPRS)评定其疗效 ,用副反应量表 (TESS)观察不良反应。结果　A、B两组治疗前后自身对照有显著性差异 (P <0 .0 1) ,两组之间比较差异无显著性 (P >0 .0 5 )。结论　利培酮治疗初发精神分裂症疗效肯定 ,常用最佳治疗剂量 <4mg d(可采用首次即达到治疗剂量 )。老年患者治疗剂量 <2mg d(可采用首次即达到治疗剂量 )。老年患者治疗剂量 <2mg d ,为正常成人剂量的5 0Objective To inquire into relation about risperidone in treatment of the first episode schizophrenia fixed dose and curative effect.Method 52 patients were divided into two groups which first dose group(A) and curative effect group(B).They were treated with risperidone for 12 weeks,it was evaluated BPRS and TESS.Results Two groups were in very noticeable difference( P <0.01) by themself.But there were no significant between A and B( P >0.05).Conclusion Risperidone was effective in schizophrenia,it was <4mg/d in general.It can be reached curative dose at once.Old patient curative dose was<2mg/d,it was 50 percent patient in general.

关 键 词：利培酮 精神分裂症 固定剂量 治疗 

分 类 号：R749.305[医药卫生—神经病学与精神病学]