中度颈动脉狭窄与脑白质疏松对认知功能的影响  

Influence of Mid Stenosis of the Carotid Arteries and Leukoaraiosis on Cognitive Function

作　　者：刘振丽[1] 王宝军[1] 刘国荣[1] 

机构地区：[1]包头市中心医院神经内科,内蒙古包头014040

出　　处：《神经损伤与功能重建》2013年第6期440-443,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:研究中度颈动脉狭窄(CAS)与轻度脑白质疏松(LA)对认知功能的影响。方法:选取中度CAS患者25例(CAS组)、中度CAS合并轻度LA患者21例(CAS+LA组)、同期无CAS和LA的患者30例(对照组),均进行简易精神状态评价量表(MMSE)、阿尔茨海默病评价量表-认知分表(ADAS-Cog)第1套、韦氏数字符号转换测验、数字广度顺背、倒背测验、语言流畅性测验、临床痴呆评定量表(CDR)、日常生活能力评定量表(ADL)测试。结果:CAS组及CAS+LA组患者MMSE、韦氏数字符号转换、数字广度顺背、倒背测验、语言流畅性测试等评分均低于对照组,ADSA-Cog评分高于对照组,差异有统计学意义(P<0.05);CAS+LA组与CAS组比较,MMSE、数字广度顺背评分减低,ADAS-cog评分增高,差异有统计学意义(P<0.05)。结论:中度CAS患者出现认知功能障碍;中度CAS与轻度LA合并时,认知功能障碍进一步加重。Objective： To study the influence of mid stenosis of the carotid arteries and leukoaraiosis on cognitive function in patients with mid carotid stenosis （CAS） and mild leukoaraiosis （LA）. Methods： Twenty-five patients with mid CAS （CAS group）, 21 patients with mid CAS and mild LA （LA group） and 30 patients without CAS nor LA （control group） were enrolled and evaluaged by mini-mental state examination （MMSE）, ADAS-Cog, WAIS numeric symbols test, digit span forward and backward test, and linguistical fluency test. Results： The MMSE, WAIS numeric symbols test, digit span forward, backward test, and linguistical fluency test scores of the CAS and LA groups were significantly lower than those in the control group whereas the scores of ADSA-Cog in the CAS and LA groups were significantly higher than that in the control group （P〈0.05）. When compared with the CAS group, the LA group showed decreased scores of the MMSE, digit span forward but increased ADAS-cog score （P〈 0.05）.Conclusion： The patients with mid CAS present cognitive dysfimction. In patients with mid CAS asso- ciated with mild LA, the cognitive dysfunction aggravated.

关 键 词：颈动脉狭窄 脑白质疏松 认知功能 

分 类 号：R741[医药卫生—神经病学与精神病学] R743.3[医药卫生—临床医学]