急性胰腺炎患者血清晚期氧化蛋白产物检测的临床意义  

The role of advanced oxidation protein products in patients with acute pancreatitis

作　　者：陈文静[1] 方春芸[1] 粱志海 唐国都[1] 覃蒙斌[1] 

机构地区：[1]广西医科大学第一附属医院消化内科,广西南宁530021

出　　处：《胃肠病学和肝病学杂志》2013年第11期1079-1081,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金(81060043);广西科学研究与技术开发计划项目(桂科攻1140003A-27)

摘　　要：目的检测急性胰腺炎患者血清晚期氧化蛋白产物(AOPP)的水平,结合IL-6及反映急性胰腺炎(AP)严重程度的指标及相关临床资料,探讨AOPP与AP严重程度的关系。方法回顾性分析我院2010年11月-2012年9月临床上确诊的AP患者58例。其中,重症急性胰腺炎(sever acute pancreatitis,SAP)18例,轻症急性胰腺炎(mild acute pancreatittis,MAP)40例。应用酶联免疫吸附试验(ELISA)方法检测AP患者入院24 h内的血清AOPP和IL-6含量。同时检测患者血常规、肝功能、血钙(Ca)、血糖(GLU)、乳酸脱氢酶(LDH)。结果 SAP组血清白细胞(WBC)、GLU、LDH高于MAP组,差异有统计学意义(P<0.05),白蛋白(ALB)、血Ca低于MAP组,差异有统计学意义(P<0.05);SAP组、MAP组血清AOPP含量分别为(38.12±11.67)ng/ml和(29.40±14.19)ng/ml,两组比较差异有统计学意义(P<0.05);SAP组、MAP组血清IL-6含量分别为(211.01±107.98)pg/ml和(129.72±56.53)pg/ml,两组比较差异有统计学意义(P<0.05)。AP患者血清AOPP与WBC、GLU呈正相关性(P<0.05),与LDH、血Ca、ALB无明显相关性(P>0.05)。结论血清AOPP增高可能与AP的严重程度有关;AOPP可能参与AP发生、发展中的炎症反应过程。Objective To investigate the relationship between AOPP and severity of AP by detecting serum levels of AOPP in patients with AP,combination the results of serum interleukin-6 （IL-6）,indicators which associated with disease severity and clinical data.Methods Fifty-eight patients who were diagnosed acute pancreatitis in our hospital from Nov.2010 to Sep.2012 were collected [18 cases of severe acute pancreatitis （SAP） and 40 cases of mild acute pancreatitis （MAP）].Serum levels of AOPP and IL-6 were dectected by enzymelinked immunosorbent assay （ELISA） within 24 hours.Blood routine,liver function,blood calcium,blood glucose and actate dehydrogenase were detected.Results Serum levels of WBC,GLU,LDH in SAP group were higher than those in MAP group （P ＜ 0.05）.ALB and blood calcium in SAP group were lower than those in MAP group （P ＜ 0.05）.Serum levels of AOPP in SAP group and MAP group were （38.12 ±11.67） ng/ml and （29.40 ± 14.19） ng/ml,respectively,and those in SAP group were higher than those in MAP group （P ＜0.05）.Serum levels of IL-6 in SAP group and MAP group were （211.01 ± 107.98）pg/ml and （129.72 ± 56.53） pg/ml,respectively,and those in SAP group were higher than those in MAP group （P ＜0.05）.AOPP was related with WBC,GLU （P ＜ 0.05）,but not related with LDH,blood calcium and ALB （P ＞0.05）.Conclusion Serum levels of AOPP may be associated with the severity of AP; AOPP may be associated with the process of inflammatory response in the occurrence and development of AP.

关 键 词：急性胰腺炎 晚期氧化蛋白产物 白介素-6 

分 类 号：R576[医药卫生—消化系统]