溃疡性结肠炎患者血浆中D-二聚体水平的影响因素  

Influence factors of plasma D-dimer levels in patients with ulcerative colitis

作　　者：李春燕 贺国斌[2] 杨明辉[2] 雷佳红[2] 向军英[2] 明文[2] 

机构地区：[1]重庆市九龙坡区第二人民医院消化内科,重庆400051 [2]川北医学院附属医院

出　　处：《胃肠病学和肝病学杂志》2013年第11期1122-1124,共3页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨溃疡性结肠炎(UC)患者血浆中D-二聚体的水平变化及其与炎症指标的关系。方法收集UC活动期患者58例、缓解期16例及正常对照24名。血沉(ESR)、C-反应蛋白(CRP)和血小板计数用传统方法检测;应用ELISA方法检测UC患者及对照组血浆IL-6、TNF-α、sICAM-1、sVCAM-1、P-选择素及D-二聚体水平。结果活动期和缓解期UC患者血浆D-二聚体水平升高的比例高于对照组,差异有统计学意义(P<0.05)。相关分析显示D-二聚体与疾病严重程度(r=0.370,P=0.010)、IL-6(r=0.369,P=0.010)、TNF-α(r=0.228,P=0.020)相关。结论疾病严重程度、IL-6和TNF-α与D-二聚体升高相关。结果提示炎症可能引起血栓形成,在UC患者炎症活动期需警惕血栓形成。Objective To investigate levels of D-dimer and its related inflammation marks in patients with ulcerative colitis （UC）.Methods 58 active UC patients,16 inactive UC patients and 24 healthy controls were enrolled.CRP,ESR and platelet counts were evaluated by traditional methods.IL-6,TNF-α,sICAM-1,sVCAM-1,P-selectin and D-dimer were measured by ELISA,and mainly analyzed by ANOVA,Pearson＇ s or Spearman＇ s correlation.Results Both active and inactive UC patients had significantly higher proportions of elevated D-dimer than healthy controls （P ＜0.05）.Correlation analysis revealed D-dimer was related with disease activity （r =0.370,P =0.010）,IL-6 （r =0.369,P=0.010）,TNF-α（r=0.228,P=0.020）.Conclusion Disease severity,IL-6 and TNF-α were associated with D-dimer increase.These results suggest that inflammation may induce thrombosis,and need vigilance for thrombosis in patients with active inflammation.

关 键 词：溃疡性结肠炎 D-二聚体 细胞因子 黏附分子 炎症 

分 类 号：R574.62[医药卫生—消化系统]